Nothing
bootsem <- function(y,x,sk,nboots=100)
{
ynames <- colnames(y)
y <- as.matrix(y)
xnames <- colnames(x)
x <- as.matrix(x)
Ny <- nrow(y)
edges <- NULL
# generate bootstrap data sets by randomly sampling the original data with replacement,
# and apply 2SPLS to each data set to infer the regulatory effects.
for (n in 1:nboots){
cat(" Bootstrap Data Set: ",n, "\n")
idx <- sample.int(Ny,size=Ny,replace=T)
booty <- y[idx,]
bootx <- x[idx,]
fit <- fitsem(booty,bootx,sk)
edges <- rbind(edges,getedges(fit))
}
# calculate the bootstrap frequency, the mean, and the standard deviation of the regulatory effects
btfreq <- aggregate(edges$weight,by=list(edges$target,edges$source),function(x) length(x)/nboots)
btmean <- aggregate(edges$weight,by=list(edges$target,edges$source),function(x) sum(x)/nboots)
btsd <- aggregate(edges$weight,by=list(edges$target,edges$source),function(x) sqrt(sum((x-sum(x)/nboots)^2)/(nboots-1)+(nboots-length(x))*(sum(x)/nboots)^2/(nboots-1)))
names(btfreq) <- c("target","source","frequency")
names(btmean) <- c("target","source","mean")
names(btsd) <- c("target","source","sd")
data.frame(boot.target=btfreq$target,boot.source=btfreq$source,boot.freq=btfreq$frequency,boot.mean=btmean$mean,boot.sd=btsd$sd)
}
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