mutagen: Mutagenicity assay

In GLMsData: Generalized Linear Model Data Sets

Mutagenicity assay

Description

The number of revertant colonies for various doses of quinoline for TA98 Salmonella

Usage

data(mutagen)

Format

A data frame with 18 observations on the following 2 variables.

Dose

the dose of quinoline; a numeric vector

Colonies

the number of revertant colonies; a numeric vector

Details

The number of revertant colonies (colonies that revert to their former gentype) for various doses of quinoline for TA98 Salmonella.

The given data represent only one replicate of the three given in Margolin, Kim and Risko (1984), but are as given in Breslow (1989).

Three plates were used for each dose, hence the three observations per dose. The data are given in order of increasing numbers of colonies.

Theory suggests one model for the data is Count = T[ 1 - exp( a - bx)]exp(-cx), for b and c greater than or equal to zero, where x is the dose of quinoline. A good approximation to this is the log-linear model log(Count) = A + B log( x + C) - Dx.

Source

N. E. Breslow (1984) Extra-Poisson variation in log-linear models. Applied Statistics, 33(1), 38–44.

References

B. H. Margolin, N. Kaplan, E. and Zeiger (1981).\ Statistical analysis of the Ames Salmonella/microsome test. Proceedings of the National Academy of Science usa, 76, 3779–3783.

Examples

data(mutagen)
summary(mutagen)

GLMsData documentation built on Aug. 22, 2022, 9:10 a.m.