Hydrogen/Deuterium eXchange Mass Spectrometry (HDX-MS) is a staple technology in structural proteomics. HaDeX provides a analytic workflow for HDX-MS data available as a standalone GUI (https://sourceforge.net/projects/HaDeX/), web server (https://hadex.mslab-ibb.pl/) and the R package available on CRAN (https://cran.r-project.org/web/packages/HaDeX/index.html).
To run HaDeX GUI locally on Windows, install it using the following binary file: https://sourceforge.net/projects/HaDeX/files/HaDeX_setup.exe/download
You can install the latest development version of the package:
devtools::install_github("hadexversum/HaDeX")
or the latest version available on CRAN:
install.packages("HaDeX")
After installation GUI can be accessed locally:
library(HaDeX)
HaDeX_gui()
The HaDeX documentation is available online.
Puchala W, Burdukiewicz M, Kistowski M, Dabrowska KA, Badaczewska-Dawid AE, Cysewski D and Dadlez M (2020). HaDeX: Analysis and Visualisation of Hydrogen/Deuterium Exchange Mass Spectrometry Data. Bioinformatics, 10.1093/bioinformatics/btaa587.
This work is supported by Foundation of Polish Science (TEAM TECH CORE FACILITY/2016-2/2 Mass Spectrometry of Biopharmaceuticals - improved methodologies for qualitative, quantitative and structural characterization of drugs, proteinaceous drug targets and diagnostic molecules).
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