calculate_confidence_limit_values: Calculate the value of confidence limit

In HaDeX: Analysis and Visualisation of Hydrogen/Deuterium Exchange Mass Spectrometry Data

Description

Calculates confidence limit values for prepared dataset, based on chosen parameters.

Usage

calculate_confidence_limit_values(
  calc_dat,
  confidence_limit = 0.98,
  theoretical = FALSE,
  relative = TRUE
)

Arguments

calc_dat	processed data from DynamX file - using prepare_dataset
confidence_limit	confidence limit chosen by user - from range [0, 1].
theoretical	logical value to determine if plot is theoretical or not.
relative	logical value to determine if values are relative or absolute.

Details

...

Value

range of confidence limit interval

References

Houde, D., Berkowitz, S.A., and Engen, J.R. (2011). The Utility of Hydrogen/Deuterium Exchange Mass Spectrometry in Biopharmaceutical Comparability Studies. J Pharm Sci 100, 2071–2086.

See Also

read_hdx prepare_dataset

Examples

# load example data
dat <- read_hdx(system.file(package = "HaDeX", "HaDeX/data/KD_180110_CD160_HVEM.csv"))

# prepare dataset for states `CD160` and `CD160_HVEM` in given time parameters 
calc_dat <- prepare_dataset(dat,
                            in_state_first = "CD160_0.001",
                            chosen_state_first = "CD160_1",
                            out_state_first = "CD160_1440",
                            in_state_second = "CD160_HVEM_0.001",
                            chosen_state_second = "CD160_HVEM_1",
                            out_state_second = "CD160_HVEM_1440")   
                            
# calculates confidence limits for prepared data  
calculate_confidence_limit_values(calc_dat = calc_dat,
                                  confidence_limit = 0.99,
                                  theoretical = FALSE, 
                                  relative = TRUE)                          
                              

HaDeX documentation built on Aug. 12, 2021, 5:20 p.m.