MCPMod: Design and Analysis of Dose-Finding Studies

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Implements a methodology for the design and analysis of dose-response studies that combines aspects of multiple comparison procedures and modeling approaches (Bretz, Pinheiro and Branson, 2005, Biometrics 61, 738-748, <doi: 10.1111/j.1541-0420.2005.00344.x>). The package provides tools for the analysis of dose finding trials as well as a variety of tools necessary to plan a trial to be conducted with the MCP-Mod methodology. Please note: The 'MCPMod' package will not be further developed, all future development of the MCP-Mod methodology will be done in the 'DoseFinding' R-package.

Author
Bjoern Bornkamp, Jose Pinheiro and Frank Bretz
Date of publication
2016-11-24 23:33:11
Maintainer
Bjoern Bornkamp <bornkamp@statistik.tu-dortmund.de>
License
GPL-3
Version
1.0-9

View on CRAN

Man pages

betaMod
Beta model
biom
Biometrics Dose Response data
critVal
Calculate critical value for multiple contrast test
emax
Emax model
exponential
Exponential (power) model
fullMod
Calculate location and scale parameters for candidate set of...
genDFdata
Simulate dose-response data
getPars
Calculate location and scale parameters
guesst
Calculate guesstimates based on prior knowledge
IBS
Irritable Bowel Syndrome Dose Response data
linear
Linear Model
linlog
Linear in log dose Model
logistic
Logistic Model
LP
Sensitivity analysis for misspecification of standardized...
MCPMod
Perform MCPMod analysis of a data set
MCPMod-internal
Internal MCPMod functions
MCPMod-package
Design and Analysis of Dose-Finding Studies
modelMeans
Calculate mean vectors for a given candidate set
mvtnorm.control
Control options for pmvt and qmvt functions
planMM
Calculate planning quantities for MCPMod
plot.fullMod
Plot method for fullMod objects
plot.LP
Plot method for LP objects
plot.MCPMod
Plot MCPMod model fits
plotModels
Plot candidate models
plot.planMM
Plotting a planMM object
plot.powerMM
Plot method for powerMM objects
powCalc
Calculate the power for the multiple contrast test
powerMM
Calculate power for different sample sizes
quadratic
Quadratic model
sampSize
Sample size calculations for MCPMod
sigEmax
Sigmoid Emax Model

Files in this package

MCPMod
MCPMod/inst
MCPMod/inst/CITATION
MCPMod/inst/README
MCPMod/inst/doc
MCPMod/inst/doc/MCPMod.pdf
MCPMod/ToDo
MCPMod/tests
MCPMod/tests/MMTests.R
MCPMod/NAMESPACE
MCPMod/NEWS
MCPMod/data
MCPMod/data/IBS.txt.gz
MCPMod/data/biom.txt.gz
MCPMod/R
MCPMod/R/analysisMM.R
MCPMod/R/planMCPMod.R
MCPMod/MD5
MCPMod/README
MCPMod/DESCRIPTION
MCPMod/ChangeLog
MCPMod/man
MCPMod/man/critVal.Rd
MCPMod/man/biom.Rd
MCPMod/man/genDFdata.Rd
MCPMod/man/IBS.Rd
MCPMod/man/quadratic.Rd
MCPMod/man/powCalc.Rd
MCPMod/man/sampSize.Rd
MCPMod/man/modelMeans.Rd
MCPMod/man/plot.planMM.Rd
MCPMod/man/MCPMod-package.Rd
MCPMod/man/plot.powerMM.Rd
MCPMod/man/logistic.Rd
MCPMod/man/getPars.Rd
MCPMod/man/exponential.Rd
MCPMod/man/powerMM.Rd
MCPMod/man/linlog.Rd
MCPMod/man/guesst.Rd
MCPMod/man/mvtnorm.control.Rd
MCPMod/man/MCPMod-internal.Rd
MCPMod/man/sigEmax.Rd
MCPMod/man/plot.MCPMod.Rd
MCPMod/man/plot.LP.Rd
MCPMod/man/linear.Rd
MCPMod/man/betaMod.Rd
MCPMod/man/planMM.Rd
MCPMod/man/emax.Rd
MCPMod/man/plotModels.Rd
MCPMod/man/LP.Rd
MCPMod/man/plot.fullMod.Rd
MCPMod/man/fullMod.Rd
MCPMod/man/MCPMod.Rd