linlog: Linear in log dose Model

Description Usage Arguments Details Value References See Also

View source: R/planMCPMod.R

Description

The model function for the linear in log model is defined as

f(d,theta)=E0+delta log(d + off),

where off is an offset parameter not estimated in the code.

Usage

1
linlog(dose, e0, delta, off = 1)

Arguments

dose

Dose variable

e0

Placebo effect

delta

Slope parameter

off

Offset value to avoid problems with dose=0 (treated as a fixed value in the code)

Details

The linear in log-dose model is intended to capture concave shapes. The parameter off is not estimated in the code but set to a pre-specified value.

Value

Response value

References

Pinheiro, J. C., Bretz, F. and Branson, M. (2006). Analysis of dose-response studies - modeling approaches, in N. Ting (ed.). Dose Finding in Drug Development, Springer, New York, pp. 146–171

See Also

logistic, sigEmax, linear, exponential, quadratic, emax, betaMod


MCPMod documentation built on March 26, 2020, 7:28 p.m.