quadratic: Quadratic model

In MCPMod: Design and Analysis of Dose-Finding Studies

Description

The model function for the quadratic model is defined as

f(d,theta)=E0+beta1 d+beta2 d^2.

Usage

quadratic(dose, e0, b1, b2)

Arguments

dose	Dose variable
e0	Placebo effect
b1	beta1 parameter
b2	beta2 parameter (controls, whether model is convex or concave)

Details

This model is intended to capture a possible non-monotonic dose-response relationship.

Value

Response value

References

Pinheiro, J. C., Bretz, F. and Branson, M. (2006). Analysis of dose-response studies - modeling approaches, in N. Ting (ed.). Dose Finding in Drug Development, Springer, New York, pp. 146–171

See Also

logistic, sigEmax, linlog, linear, exponential, emax, betaMod

MCPMod documentation built on March 26, 2020, 7:28 p.m.