MiRKAT: Microbiome Regression-Based Kernel Association Test

Test for overall association between microbiome composition data with a continuous or dichotomous outcome via phylogenetic kernels. The phenotype can be univariate continuous or binary phenotypes (Zhao et al. (2015) <doi:10.1016/j.ajhg.2015.04.003>), survival outcomes (Plantinga et al. (2017) <doi:10.1186/s40168-017-0239-9>), multivariate (Zhan et al. (2017) <doi:10.1002/gepi.22030>) and structured phenotypes (Zhan et al. (2017) <doi:10.1111/biom.12684>). For all these effect, the microbiome community effect was modeled nonparametrically through a kernel function, which can incorporate the phylogenetic tree information.

Package details

AuthorHaotian Zheng [aut], Xiang Zhan [aut], Anna Plantinga [aut], Michael Wu [aut], Ni Zhao [aut, cre], Jun Chen [aut]
MaintainerNi Zhao <[email protected]>
LicenseGPL (>= 2)
Version1.0.1
Package repositoryView on CRAN
Installation Install the latest version of this package by entering the following in R:
install.packages("MiRKAT")

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MiRKAT documentation built on April 26, 2018, 1:04 a.m.