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MicroSEC: Sequence Error Filter for Formalin-Fixed and Paraffin-Embedded Samples
Clinical sequencing of tumor is usually performed on formalin-fixed and paraffin-embedded samples and have many sequencing errors. We found that the majority of these errors are detected in chimeric read caused by single-strand DNA with micro-homology. Our filtering pipeline focuses on the uneven distribution of the artifacts in each read and removes such errors in formalin-fixed and paraffin-embedded samples without over-eliminating the true mutations detected in fresh frozen samples.
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Package details |
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| Author | Masachika Ikegami [aut, cre] |
| Maintainer | Masachika Ikegami <ikegamitky@gmail.com> |
| License | MIT + file LICENSE |
| Version | 2.1.6 |
| URL | https://github.com/MANO-B/MicroSEC/ |
| Package repository | View on CRAN |
| Installation |
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