gAUC: General Area Under the Curve

In NonCompart: Noncompartmental Analysis for Pharmacokinetic Data

General Area Under the Curve

Description

General AUC function for Emax, TEmax and AUCs

Usage

gAUC(x, y, Ymax = "Emax", XofYmax = "TEmax", AUCname = "AUEClast", iAUC = "", 
     Outer = "NEAREST")

Arguments

x	usually time
y	usually concentration or effect. This can be negative/
Ymax	usually Cmax or Emax
XofYmax	usually Tmax or TEmax
AUCname	usually AUClast or AUEClast
iAUC	a data.frame to calculate interval AUCs
Outer	indicates how to do the out of x range point

Details

This is a general purpose AUC function. It calculates only Cmax(Emax), Tmax(TEmax) and AUCs(AUECs). This can be used for effect(pharmacodynamic) data which has negative values. For concentration data, use IntAUC.

Value

Column names can vary according to the options.

Emax	maximum y value
TEmax	x value at the maximum y value
AUEClast	Area under the y versus x curve
iAUCs	Columns from iAUC input

Author(s)

Kyun-Seop Bae <[e-mail]>

Examples

# For one subject
x = Theoph[Theoph$Subject=="1", "Time"]
y = Theoph[Theoph$Subject=="1", "conc"]
gAUC(x, y)

iAUC = data.frame(Name=c("AUC[0-12h]","AUC[0-24h]"), Start=c(0,0), End=c(12,24))
gAUC(x, y, iAUC=iAUC)

NonCompart documentation built on Nov. 15, 2023, 9:06 a.m.