tblNCA: Table output NCA

In NonCompart: Noncompartmental Analysis for Pharmacokinetic Data

Table output NCA

Description

Do multiple NCA and returns a result table. See sNCA for more detail i.e. iAUC

Usage

tblNCA(concData, key = "Subject", colTime = "Time", colConc = "conc", dose = 0, 
       adm = "Extravascular", dur = 0, doseUnit = "mg", timeUnit = "h", 
       concUnit = "ug/L", down = "Linear", R2ADJ = 0, MW = 0, SS = FALSE, 
       iAUC = "", excludeDelta = 1)

Arguments

concData	concentration data table
key	column names of concData to be shown in the output table
colTime	column name for time
colConc	column name for concentration
dose	administered dose
adm	one of "Bolus" or "Infusion" or "Extravascular" to indicate drug administration mode
dur	duration of infusion
doseUnit	unit of dose
timeUnit	unit of time
concUnit	unit of concentration
down	method to calculate AUC, "Linear" or "Log"
R2ADJ	Lowest threshold of adjusted R-square value to do manual slope determination
MW	molecular weight of drug
SS	if steady-state, this should be TRUE. AUCLST (AUClast) is used instead of AUCIFO (AUCinf) for the calculation of Vz (VZFO, VZO), CL (CLFO, CLO), and Vdss (VSSO).
iAUC	data.frame for interval AUC
excludeDelta	Improvement of R2ADJ larger than this value could exclude the last point. Default value 1 is for the compatibility with other software.

Details

Tabular output of NCA with many subjects. Author recommends to use excludeDelta option with about 0.3.

Value

Basically same with sNCA

Author(s)

Kyun-Seop Bae <[e-mail]>

See Also

help, sNCA

Examples

tblNCA(Theoph, key="Subject", dose=320, concUnit="mg/L")
tblNCA(Indometh, key="Subject", colTime="time", colConc="conc", dose=25, 
       adm="Infusion", dur=0.5, concUnit="mg/L")

NonCompart documentation built on Nov. 15, 2023, 9:06 a.m.