Purpose of this package is it to plan, monitor and evaluate oncological phase II studies. In general this kind of studies are single-arm trials with planned interim analysis and binary endpoint. To meet the resulting requirements, the package provides functions to calculate and evaluate 'Simon's two-stage designs' and 'so-called' 'subset designs'. If you are unfamiliar with this package a good starting point is to take a closer look at the functions getSolutions() and getSolutionsSub1().The web-based tool (https://imbi.shinyapps.io/phaseII-app/) extends the functionality of our R package by means of a proper dealing with over- and underrunning. The R function binom.test of the 'stats' R package and the package 'binom' might be helpful to assess the performance of the corresponding one-stage design as a reference.

Author | Marius Wirths |

Date of publication | 2016-05-23 11:28:04 |

Maintainer | Marius Wirths <wirths@imbi.uni-heidelberg.de> |

License | GPL (>= 2) |

Version | 0.1.6 |

**getCE:** Calculates the conditional error.

**get_CI:** Calculates the confidence interval.

**get_conditionalPower:** Calculates the conditional power.

**get_confidence_set:** Calculates the confidence set.

**getCP:** Calculates the conditional power.

**getCP_simon:** Returns the conditional power.

**getD_distributeToOne:** Get the conditional errors.

**getD_equally:** Get the conditional errors equally.

**getD_none:** Get the conditional errors.

**getD_proportionally:** Get the conditional errors proportionally.

**getN2:** Calculates the number of patients which should be enrolled in...

**getP:** Calculates the p-value (binomial test).

**get_p_exact_subset:** Calculates the exact p value.

**get_p_KC:** Calculates the p-value.

**get_r2_flex:** Calculates the number of responses needed for the second...

**getSolutions:** Returns designs for a given "simon"-object (see 'setupSimon')

**getSolutionsSub1:** Calculates designs for a given "sub1"-object.

**get_UMVUE_GMS:** Calculates the "uniformly minimal variance unbiased...

**get_UMVUE_GMS_subset_second_only:** Calculates the "uniformly minimal variance unbiased...

**get_UMVUE_GMS_subset_second_total:** Calculates the "uniformly minimal variance unbiased...

**plot_confidence_set:** Plots the "confidence set" according to the observed...

**plot_simon_study_state:** Plots the study state of a given Simon's two-stage design.

**plot_sub1_study_state:** Plots the study state of a given subset design.

**setSimonParams:** Sets the parameters for a given "simon"-object.

**setSub1Params:** Sets the parameters for a given "sub1"-object.

**setupSimon:** Creates a "simon"-object.

**setupSub1Design:** Creates a "sub1"-object.

**simon_module:** Functions and Objects created by Rcpp for the "Simon's...

**sub1_module:** Functions and Objects created by Rcpp for the "subset design"

**toDataframe:** Helper function for 'getSolutions' and 'getSolutionsSub1'.

OneArmPhaseTwoStudy

OneArmPhaseTwoStudy/src

OneArmPhaseTwoStudy/src/result.cpp

OneArmPhaseTwoStudy/src/Makevars

OneArmPhaseTwoStudy/src/simon.cpp

OneArmPhaseTwoStudy/src/result.h

OneArmPhaseTwoStudy/src/design.h

OneArmPhaseTwoStudy/src/resultsub1.cpp

OneArmPhaseTwoStudy/src/sub1.h

OneArmPhaseTwoStudy/src/sub1.cpp

OneArmPhaseTwoStudy/src/resultsub1.h

OneArmPhaseTwoStudy/src/simon.h

OneArmPhaseTwoStudy/src/simonModule.h

OneArmPhaseTwoStudy/src/design.cpp

OneArmPhaseTwoStudy/src/Makevars.win

OneArmPhaseTwoStudy/src/sub1Module.h

OneArmPhaseTwoStudy/NAMESPACE

OneArmPhaseTwoStudy/R

OneArmPhaseTwoStudy/R/zzz.R
OneArmPhaseTwoStudy/MD5

OneArmPhaseTwoStudy/DESCRIPTION

OneArmPhaseTwoStudy/man

OneArmPhaseTwoStudy/man/getSolutionsSub1.Rd
OneArmPhaseTwoStudy/man/getP.Rd
OneArmPhaseTwoStudy/man/simon_module.Rd
OneArmPhaseTwoStudy/man/get_p_exact_subset.Rd
OneArmPhaseTwoStudy/man/get_UMVUE_GMS_subset_second_only.Rd
OneArmPhaseTwoStudy/man/get_confidence_set.Rd
OneArmPhaseTwoStudy/man/plot_simon_study_state.Rd
OneArmPhaseTwoStudy/man/getD_none.Rd
OneArmPhaseTwoStudy/man/get_conditionalPower.Rd
OneArmPhaseTwoStudy/man/get_UMVUE_GMS.Rd
OneArmPhaseTwoStudy/man/sub1_module.Rd
OneArmPhaseTwoStudy/man/get_r2_flex.Rd
OneArmPhaseTwoStudy/man/getCP_simon.Rd
OneArmPhaseTwoStudy/man/getSolutions.Rd
OneArmPhaseTwoStudy/man/setupSimon.Rd
OneArmPhaseTwoStudy/man/plot_sub1_study_state.Rd
OneArmPhaseTwoStudy/man/getCE.Rd
OneArmPhaseTwoStudy/man/get_UMVUE_GMS_subset_second_total.Rd
OneArmPhaseTwoStudy/man/getN2.Rd
OneArmPhaseTwoStudy/man/get_p_KC.Rd
OneArmPhaseTwoStudy/man/getD_distributeToOne.Rd
OneArmPhaseTwoStudy/man/setSub1Params.Rd
OneArmPhaseTwoStudy/man/getD_equally.Rd
OneArmPhaseTwoStudy/man/getD_proportionally.Rd
OneArmPhaseTwoStudy/man/toDataframe.Rd
OneArmPhaseTwoStudy/man/setSimonParams.Rd
OneArmPhaseTwoStudy/man/setupSub1Design.Rd
OneArmPhaseTwoStudy/man/getCP.Rd
OneArmPhaseTwoStudy/man/plot_confidence_set.Rd
OneArmPhaseTwoStudy/man/get_CI.Rd
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