Purpose of this package is it to plan, monitor and evaluate oncological phase II studies. In general this kind of studies are singlearm trials with planned interim analysis and binary endpoint. To meet the resulting requirements, the package provides functions to calculate and evaluate 'Simon's twostage designs' and 'socalled' 'subset designs'. If you are unfamiliar with this package a good starting point is to take a closer look at the functions getSolutions() and getSolutionsSub1().The webbased tool (https://imbi.shinyapps.io/phaseIIapp/) extends the functionality of our R package by means of a proper dealing with over and underrunning. The R function binom.test of the 'stats' R package and the package 'binom' might be helpful to assess the performance of the corresponding onestage design as a reference.
Author  Marius Wirths 
Date of publication  20160523 11:28:04 
Maintainer  Marius Wirths <wirths@imbi.uniheidelberg.de> 
License  GPL (>= 2) 
Version  0.1.6 
Package repository  View on CRAN 
Installation  Install the latest version of this package by entering the following in R:

All man pages Function index File listing
Man pages  

getCE: Calculates the conditional error.  
get_CI: Calculates the confidence interval.  
get_conditionalPower: Calculates the conditional power.  
get_confidence_set: Calculates the confidence set.  
getCP: Calculates the conditional power.  
getCP_simon: Returns the conditional power.  
getD_distributeToOne: Get the conditional errors.  
getD_equally: Get the conditional errors equally.  
getD_none: Get the conditional errors.  
getD_proportionally: Get the conditional errors proportionally.  
getN2: Calculates the number of patients which should be enrolled in...  
getP: Calculates the pvalue (binomial test).  
get_p_exact_subset: Calculates the exact p value.  
get_p_KC: Calculates the pvalue.  
get_r2_flex: Calculates the number of responses needed for the second...  
getSolutions: Returns designs for a given "simon"object (see 'setupSimon')  
getSolutionsSub1: Calculates designs for a given "sub1"object.  
get_UMVUE_GMS: Calculates the "uniformly minimal variance unbiased...  
get_UMVUE_GMS_subset_second_only: Calculates the "uniformly minimal variance unbiased...  
get_UMVUE_GMS_subset_second_total: Calculates the "uniformly minimal variance unbiased...  
plot_confidence_set: Plots the "confidence set" according to the observed...  
plot_simon_study_state: Plots the study state of a given Simon's twostage design.  
plot_sub1_study_state: Plots the study state of a given subset design.  
setSimonParams: Sets the parameters for a given "simon"object.  
setSub1Params: Sets the parameters for a given "sub1"object.  
setupSimon: Creates a "simon"object.  
setupSub1Design: Creates a "sub1"object.  
simon_module: Functions and Objects created by Rcpp for the "Simon's...  
sub1_module: Functions and Objects created by Rcpp for the "subset design"  
toDataframe: Helper function for 'getSolutions' and 'getSolutionsSub1'. 
Functions 

Files  

src
 
src/result.cpp
 
src/Makevars
 
src/simon.cpp
 
src/result.h
 
src/design.h
 
src/resultsub1.cpp
 
src/sub1.h
 
src/sub1.cpp
 
src/resultsub1.h
 
src/simon.h
 
src/simonModule.h
 
src/design.cpp
 
src/Makevars.win
 
src/sub1Module.h
 
NAMESPACE
 
R
 
R/zzz.R  
MD5
 
DESCRIPTION
 
man
 
man/getSolutionsSub1.Rd  
man/getP.Rd  
man/simon_module.Rd  
man/get_p_exact_subset.Rd  
man/get_UMVUE_GMS_subset_second_only.Rd  
man/get_confidence_set.Rd  
man/plot_simon_study_state.Rd  
man/getD_none.Rd  
man/get_conditionalPower.Rd  
man/get_UMVUE_GMS.Rd  
man/sub1_module.Rd  
man/get_r2_flex.Rd  
man/getCP_simon.Rd  
man/getSolutions.Rd  
man/setupSimon.Rd  
man/plot_sub1_study_state.Rd  
man/getCE.Rd  
man/get_UMVUE_GMS_subset_second_total.Rd  
man/getN2.Rd  
man/get_p_KC.Rd  
man/getD_distributeToOne.Rd  
man/setSub1Params.Rd  
man/getD_equally.Rd  
man/getD_proportionally.Rd  
man/toDataframe.Rd  
man/setSimonParams.Rd  
man/setupSub1Design.Rd  
man/getCP.Rd  
man/plot_confidence_set.Rd  
man/get_CI.Rd 
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