Description Usage Arguments References Examples

Calculates the p-value for a Simon's two-stage design based on the work from Koyama and Chen.

1 | ```
get_p_KC(k, r1, n1, n, p0)
``` |

`k` |
overall observed responses. |

`r1` |
critical value for the first stage. |

`n1` |
sample size for the first stage. |

`n` |
overall sample size. |

`p0` |
response probability under the null hypothesis. |

Koyama T and Chen H (2008): Proper inference from Simon's two-stage designs. Statistics in Medicine, 27(16):3145-3154.

1 2 3 4 5 6 7 | ```
#Calculate a Simon's two-stage design
design <- getSolutions()$Solutions[3,] #minimax-design for the default values.
#Assume 9 responses were observed in the whole trial.
k = 9
p_val <- get_p_KC(k, design$r1, design$n1, design$n, design$p0)
``` |

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