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#' Cross-validation for \code{PCLasso2}
#'
#' Perform k-fold cross validations for the PCLasso2 model with grouped
#' covariates over a grid of values for the regularization parameter
#' \code{lambda}.
#'
#' @param x A n x p design matrix of gene/protein expression measurements with n
#' samples and p genes/proteins, as in \code{PCLasso2}.
#' @param y The response vector.
#' @param group A list of groups as in \code{PCLasso}. The feature
#' (gene/protein) names in \code{group} should be consistent with the feature
#' (gene/protein) names in \code{x}.
#' @param penalty The penalty to be applied to the model. For group selection,
#' one of grLasso, grMCP, or grSCAD. See \code{grpreg} in the R package
#' \code{grpreg} for details.
#' @param family Either "binomial" or "gaussian", depending on the response.
#' @param nfolds The number of cross-validation folds. Default is 5.
#' @param gamma Tuning parameter of the \code{grSCAD}/\code{grMCP} penalty.
#' Default is 8.
#' @param standardize Logical flag for \code{x} standardization, prior to
#' fitting the model. Default is \code{TRUE}.
#' @param ... Arguments to be passed to \code{cv.grpreg} in the R package
#' \code{grpreg}.
#'
#' @details The function calls \code{PCLasso2} \code{nfolds} times, each time
#' leaving out 1/\code{nfolds} of the data. The cross-validation error is based
#' on the deviance. The numbers for each class are balanced across the folds;
#' i.e., the number of outcomes in which y is equal to 1 is the same for each
#' fold, or possibly off by 1 if the numbers do not divide evenly. See
#' \code{cv.grpreg} in the R package \code{grpreg} for details.
#'
#' @return An object with S3 class "cv.PCLasso2" containing: \item{cv.fit}{ An
#' object of class "cv.grpreg".} \item{complexes.dt}{ Complexes with features
#' (genes/proteins) not included in \code{x} being filtered out. }
#' @import grpreg
#' @export
#'
#' @examples
#' # load data
#' data(classData)
#' data(PCGroups)
#'
#' x = classData$Exp
#' y = classData$Label
#'
#' PC.Human <- getPCGroups(Groups = PCGroups, Organism = "Human",
#' Type = "GeneSymbol")
#'
#' # fit model
#' cv.fit1 <- cv.PCLasso2(x, y, group = PC.Human, penalty = "grLasso",
#' family = "binomial", nfolds = 5)
#'
#' \donttest{
#' cv.fit1 <- cv.PCLasso2(x, y, group = PC.Human, penalty = "grSCAD",
#' family = "binomial", nfolds = 5, gamma = 10)
#' cv.fit1 <- cv.PCLasso2(x, y, group = PC.Human, penalty = "grMCP",
#' family = "binomial", nfolds = 5, gamma = 15)}
#'
#' @references
#' PCLasso2: a protein complex-based, group Lasso-logistic model for risk
#' protein complex discovery. To be published.
#'
#' Park, H., Niida, A., Miyano, S. and Imoto, S. (2015) Sparse overlapping group
#' lasso for integrative multi-omics analysis. Journal of computational biology:
#' a journal of computational molecular cell biology, 22, 73-84.
#' @author Wei Liu
#' @seealso \code{\link{predict.cv.PCLasso2}}
cv.PCLasso2 <-
function(x, y, group,
penalty = c("grLasso", "grMCP", "grSCAD"),
family=c("binomial", "gaussian", "poisson"),
nfolds = 5,
gamma = 8,
standardize = TRUE,...){
penalty <- match.arg(penalty)
family = match.arg(family)
if(standardize){
x <- scale(x, center = TRUE, scale = TRUE)
}
# feature set in all groups
featureSet <- unique(unlist(group))
# common features in groups and expression matrix x
commonFeat <- intersect(colnames(x), featureSet)
# filter undetected genes in expression matrix x
x <- x[,commonFeat]
# filter undetected genes in groups
# Construct groups whose expressions are detected
group.dt <- vector(mode = "list", length = 0)
idx <- 0
for(i in 1:length(group)){
group.i <- intersect(group[[i]], commonFeat)
if(length(group.i) > 1){
idx <- idx + 1
group.dt[[idx]] <- group.i
names(group.dt)[idx] <- names(group)[i]
}
}
# Filter duplicate groups (generated due to undetected genes)
group.dt <- group.dt[!duplicated(group.dt)]
# extended genes
commonFeat.ext <- unlist(group.dt)
# New names of extended genes
# The new name consists of "group+_+gene name"
commonFeat.extName <- c()
for(i in 1:length(group.dt)){
names.i <- paste0(names(group.dt)[i], "_", group.dt[[i]])
commonFeat.extName <- c(commonFeat.extName, names.i)
}
# group of extended genes
groupOfFeats <- c()
for(i in 1:length(group.dt)){
group.i <- rep(names(group.dt)[i], length = length(group.dt[[i]]))
groupOfFeats <- c(groupOfFeats, group.i)
}
# extended dataset
x.ext <- x[, commonFeat.ext]
colnames(x.ext) <- commonFeat.extName
# grpsurv
cv.fit <- grpreg::cv.grpreg(X=x.ext,
y=y,
group = groupOfFeats,
penalty = penalty,
nfolds = nfolds,
gamma = gamma,
family = family,...)
res <- list(cv.fit = cv.fit, complexes.dt = group.dt)
class(res) <- "cv.PCLasso2"
return(res)
}
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