apply_duration_scale: Apply infusion duration scale to a regimen

In PKPDsim: Tools for Performing Pharmacokinetic-Pharmacodynamic Simulations

Apply infusion duration scale to a regimen

Description

E.g. see Centanni et al. Clin Pharmacokinet 2024. An estimated scaling factor for the length of the infusion was applied there in a model for vincristine. This is likely most relevant for very short infusions.

Usage

apply_duration_scale(
  regimen,
  duration_scale = NULL,
  parameters = NULL,
  cmt_mapping = NULL
)

Arguments

regimen	PKPDsim regimen
duration_scale	infusion length scale.
parameters	parameter list, required if the duration scale is specified as a parameter.
cmt_mapping	map of administration types to compartments, e.g. list("oral" = 1, "infusion" = 2, "bolus" = 2).

Details

Implementation is similar to handling of lagtime, i.e. the regimen that is the input for the simulation function is updated.

Value

Original regimen with infusion lengths scaled by a factor

PKPDsim documentation built on June 8, 2025, 10:32 a.m.