calc_ss_analytic: Returns the state of a linear PK system at steady state...

In PKPDsim: Tools for Performing Pharmacokinetic-Pharmacodynamic Simulations

Returns the state of a linear PK system at steady state (trough) using analytics equations (so for linear PK systems only).

Description

Basically it performs a PK simulation using analytic equations instead of ODEs to steady state (n=45 days, increased if needed).

Usage

calc_ss_analytic(
  f = "1cmt_oral",
  dose,
  interval,
  t_inf = NULL,
  model,
  parameters,
  covariates = NULL,
  map = NULL,
  n_days = 45,
  n_transit_compartments = 0,
  auc = FALSE
)

Arguments

f	analytic equation to use, must be one of 'names(advan_funcs)'
dose	dose
interval	interval
t_inf	infusion time
model	PKPDsim model
parameters	parameters list
covariates	covariates list
map	list for remapping parameters, ex: 'list(CL = "CL", V = "V")'
n_days	number of days at which to assume steady state. Default is 45.
n_transit_compartments	number of transit compartments, will insert n compartments between the first (dose) compartment and the second (central) compartment.
auc	add (empty) AUC compartment at end of state vector?

Details

It can also be used for models with transit compartments, however, the assumption is made that at the end of the dosing interval the amount in the transit compartments is negligible (0).

Value

State vector of a linear pharmacokinetic system at steady state

PKPDsim documentation built on March 7, 2023, 5:40 p.m.