new_covariate: New covariate

In PKPDsim: Tools for Performing Pharmacokinetic-Pharmacodynamic Simulations

New covariate

Description

Describe data for a covariate, either fixed or time-variant

Usage

new_covariate(
  value = NULL,
  times = NULL,
  implementation = "interpolate",
  unit = NULL,
  interpolation_join_limit = 1,
  remove_negative_times = TRUE,
  round_times = NULL,
  comments = NULL,
  verbose = TRUE
)

Arguments

value	a numeric vector
times	NULL for time-invariant covariate or a numeric vector specifying the update times for the covariate
implementation	for time-varying covariates either 'LOCF' (last observation carried forward) or 'interpolate' (default)
unit	specify covariate unit (optional, for documentation purposes only)
interpolation_join_limit	for interpolate option, if covariate timepoints are spaced too close together, the ODE solver sometimes chokes. This argument sets a lower limit on the space between timepoints. It will create average values on joint timepoints instead. If undesired set to NULL or 0.
remove_negative_times	TRUE`` or FALSE'
round_times	round times to specified number of digits. If NULL, will not round.
comments	NULL, or vector of length equal to value specifying comments to each observation
verbose	verbosity

Value

Object of class "covariate"

PKPDsim documentation built on March 7, 2023, 5:40 p.m.