TRD: Transmission Ratio Distortion

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Transmission Ratio Distortion (TRD) is a genetic phenomenon where the two alleles from either parent are not transmitted to the offspring at the expected 1:1 ratio under Mendelian inheritance, leading to spurious signals in genetic association studies. Functions in this package are developed to account for this phenomenon using loglinear model and Transmission Disequilibrium Test (TDT). Some population information can also be calculated.

Author
Lam Opal Huang
Date of publication
2015-11-11 00:41:56
Maintainer
Lam Opal Huang <opal.huang@mail.mcgill.ca>
License
GPL (>= 2)
Version
1.1

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Man pages

find.maf
Find minor allele frequency (MAF) in case-trios,...
find.t
Find transmission ratio of minor alleles in mother, father or...
gcount
Calculate genotype counts (additive model) for selected...
ll
Fit Loglinear model with and without adjustment for TRD.
prev
Calculate theoretical prevalence of disease
rtrios
Generate simulated popoulation of case- and control-trios
strata.cnt
Count trios for each of the 15/16 strata with...
tdt
Compute TDT and adjusted TDT on case- and/or control-trios
TRD-package
Transmission Ratio Distortion

Files in this package

TRD
TRD/NAMESPACE
TRD/R
TRD/R/ll.gdi.R
TRD/R/rtrios.R
TRD/R/ll.grri.R
TRD/R/find.t.R
TRD/R/out.stats.R
TRD/R/tdt.cnt.R
TRD/R/ll.grr.R
TRD/R/find.maf.R
TRD/R/tdt.R
TRD/R/prev.R
TRD/R/ll.R
TRD/R/ll.dom.R
TRD/R/gcount.R
TRD/R/ll.domi.R
TRD/R/strata.cnt.R
TRD/R/ll.gd.R
TRD/MD5
TRD/DESCRIPTION
TRD/man
TRD/man/find.t.Rd
TRD/man/rtrios.Rd
TRD/man/ll.Rd
TRD/man/gcount.Rd
TRD/man/TRD-package.Rd
TRD/man/prev.Rd
TRD/man/find.maf.Rd
TRD/man/strata.cnt.Rd
TRD/man/tdt.Rd