Transmission Ratio Distortion (TRD) is a genetic phenomenon where the two alleles from either parent are not transmitted to the offspring at the expected 1:1 ratio under Mendelian inheritance, leading to spurious signals in genetic association studies. Functions in this package are developed to account for this phenomenon using loglinear model and Transmission Disequilibrium Test (TDT). Some population information can also be calculated.
|Author||Lam Opal Huang|
|Date of publication||2015-11-11 00:41:56|
|Maintainer||Lam Opal Huang <firstname.lastname@example.org>|
|License||GPL (>= 2)|
find.maf: Find minor allele frequency (MAF) in case-trios,...
find.t: Find transmission ratio of minor alleles in mother, father or...
gcount: Calculate genotype counts (additive model) for selected...
ll: Fit Loglinear model with and without adjustment for TRD.
prev: Calculate theoretical prevalence of disease
rtrios: Generate simulated popoulation of case- and control-trios
strata.cnt: Count trios for each of the 15/16 strata with...
tdt: Compute TDT and adjusted TDT on case- and/or control-trios
TRD-package: Transmission Ratio Distortion