Description Usage Arguments Value Author(s) See Also Examples
Compute MAF in child, parents and triad of case-trios, control-trios, or the whole sample. Minor allele normally refers to the disease allele, which has lower frequency than the alternative allele(s). Trios with partially missing data are included.
1 |
sample |
case- and/or control-trios dataset with first column as disease status (1=case, 0=control), the second, third and forth columns as maternal, paternal and child genotypes. The fifth column, if entered as part of the input data, is the parent-of-origin indicator of disease allele in a heterozygous child (a value of 1 indicates the mother transmitted the disease allele and 0 indicates the father transmitted). The parent-of-origin indicator is only meaningful for a heterozygous child. |
cases |
MAF in affected children, parents, or triads of case-trios |
ctrls |
MAF in unaffected children, parents, or triads of control-trios |
sample |
MAF in children, parents, or triads of the whole sample |
Lam Opal Huang
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