Description Usage Arguments Value Author(s) See Also Examples
Calculate the transmission ratio of the minor allele from parents to offspring for case- and control-trios, in mother, father, or both parents. Minor allele normally refers to the disease allele, which has lower frequency than the alternative allele(s). Note that trios with missing data are discarded.
1 |
sample |
case- and/or control-trios dataset with first column as disease status (1=case, 0=control), the second, third and forth columns as maternal, paternal and child genotypes. The fifth column, if entered as part of the input data, is the parent-of-origin indicator of disease allele in a heterozygous child (a value of 1 indicates the mother transmitted the disease allele and 0 indicates the father transmitted). The parent-of-origin indicator is only meaningful for a heterozygous child. |
cases |
transmission ratio of minor allele from mother, father and both parents of case-trios to the offspring |
ctrls |
transmission ratio of minor allele from mother, father and both parents of control-trios to the offspring |
Lam Opal Huang
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