rtrios: Generate simulated popoulation of case- and control-trios
In TRD: Transmission Ratio Distortion

Description Usage Arguments Value Author(s) See Also Examples

Using penetrance factors, ratio of maternal- to paternal-induced disease risk for a heterozygous child, tranmission ratio of minor allele from mother and father to offspring, and minor allele frequency (MAF) to generate a simulated population of case- and/or control-trios dataset with first column as disease status (1=case, 0=control), the second, third and forth columns as maternal, paternal and child genotypes. The fifth column as the parent-of-origin indicator of disease allele in a heterozygous child (a value of 1 indicates the mother transmitted the disease allele and 0 indicates the father transmitted). The parent-of-origin indicator is only meaningful for a heterozygous child. Minor allele normally refers to the disease allele, which has lower frequency than the alternative allele(s).

1	rtrios(n, ssize, f0, f1, f2, g, tmother, tfather, maf)

`n`	simulated population size
`ssize`	sample size
`f0`	penetrance for individuals with genotype 0 (additive model)
`f1`	penetrance for individuals with genotype 1 (additive model)
`f2`	penetrance for individuals with genotype 2 (additive model)
`g`	Ratio of maternal- over paternal-induced disease risk
`tmother`	transmission ratio of minor allele from mother to child
`tfather`	transmission ratio of minor allele from father to child
`maf`	minor allele frequency