Using V-algorithm and Newton-Raphson Method to Obtain Multiple-objective Optimal Design.

Description

Using V-algorithm and Newton-Raphson method to obtain multiple-objective optimal design for estimating the shape of dose-response, the ED50 (the dose producing an effect midway between the expected responses at the extreme doses) and the MED (the minimum effective dose level) for the 2,3,4-parameter logistic models and for evaluating its efficiencies for the three objectives.

Details

Package: VNM
Type: Package
Version: 1.0.1
Date: 2016-01-15
License: GPL-2

Author(s)

Seung Won Hyun, Weng Kee Wong, and Yarong Yang

References

Seung Won Hyun, Weng Kee Wong, and Yarong Yang (2014), VNM: An R Package for Finding Multiple-Objective Optimal Designs for the 4-Parameter Logistic Model, submitted to Journal of Statistical Software.

Seung Won Hyun and Weng Kee Wong (2015), Multiple Objective Optimal Designs to Study the Interesting Features in a Dose-Response Relationship, accepted by the International Journal of Biostatistics.

Examples

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MOPT(LB = -1, UB = 1, P = c(exp(-1/3),3),lambda = c(1/3,1/3), 
delta = 0.2, r = 10,grid=.01, verbose=TRUE)