Plot the estimated dose-toxicity curve

Description

The estimated dose-toxicity curve using the Bayesian continuous reassessment method is plotted for the patients thus far recruited into the trial

Usage

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## S3 method for class 'bcrm'
plot(x, file = NULL, each = FALSE, trajectory = FALSE, ...)

Arguments

x

An object of class "bcrm", as returned by bcrm

each

Should posterior summaries be plotted after each recruited cohort? Defaults to FALSE.

trajectory

Should the sequential dose trajectory of the recruited patients be plotted, along with the observed toxicities? Defaults to FALSE.

file

File name where the dose-response plots are stored, in a pdf format. The program will ammend the current sample size to the end of the file name.

...

Further arguments passed to or from other methods

Details

The estimated 2.5%, 25%, 50%, 75%, 97.5% quantiles of the probability of toxicity are plotted for each dose. Additionally, a histogram of the number of toxicities and non-toxicities is plotted at each experimented dose.

If trajectory = TRUE then the sequential dose trajectory and observed toxicities are plotted.

Author(s)

Michael Sweeting mjs212@medschl.cam.ac.uk (University of Cambridge, UK)

References

Sweeting M., Mander A., Sabin T. bcrm: Bayesian Continual Reassessment Method Designs for Phase I Dose-Finding Trials. Journal of Statistical Software (2013) 54: 1–26. http://www.jstatsoft.org/article/view/v054i13

See Also

bcrm