Print information regarding the operating characteristics of a standard 3+3 design

Share:

Description

Print method for a 3+3 design specified using a threep3.

Usage

1
2
## S3 method for class 'threep3'
print(x, tox.cutpoints = NULL, dose = NULL, ...)

Arguments

x

An object of class "threep3" as returned by threep3

tox.cutpoints

An optional argument passed to print.threep3 specifying the cutpoints of toxicity for which the operating characteristics are to be categorised. Defaults to seq(from=0,to=1,by=0.2)

dose

Optional vector of length k of actual doses for presentation purposes

...

Further arguments passed to or from other methods

Details

The following operating characteristics are printed for the standard 3+3 design:

Sample size

Mean, minimum and maximum sample size of the design

Experimentation proportion

Proportion of patients recruited to each dose, and to each true region of toxicity, on average

Recommendation proportion

Proportion of 3+3 trials that would recommend each of the dose levels as the final maximum tolerated dose (see threep3 for definition of the MTD), and the associated regions of true toxicity for the recommended MTDs

Average number of patients

The average number of patients dosed at each level

Average number of DLTs

The average number of DLTs seen at each level

Author(s)

Michael Sweeting mjs212@medschl.cam.ac.uk (University of Cambridge, UK)

References

Sweeting M., Mander A., Sabin T. bcrm: Bayesian Continual Reassessment Method Designs for Phase I Dose-Finding Trials. Journal of Statistical Software (2013) 54: 1–26. http://www.jstatsoft.org/article/view/v054i13

See Also

threep3