emaxsolve: Solve Emax function for target value

In clinDR: Simulation and Analysis Tools for Clinical Dose Response Modeling

Solve Emax function for target value

Description

Solve the Emax function for dose or Emax to yield a specified response.

Usage

solveEmax(target,dose,led50,lambda,e0,pboadj=TRUE)
solveDose(target,led50,lambda,emax,e0,pboadj=TRUE)

Arguments

target	The targetted response. If the Emax model is specified on the logit scale for binary data, target and e0 must be logit transformed also.
dose	The dose yielding target. It is specifed for solveEmax, and returned for solveDose
led50, lambda, e0	Emax model parameters (ed50 log transformed)
emax	The Emax model parameter for solveDose. The value returned for solveEmax
pboadj	When TRUE, target is placebo-adjusted.

Author(s)

Neal Thomas

See Also

fitEmax, fitEmaxB, emaxsim, emaxsimB

Examples

e0<-10
dose<-1
led50<-log(0.5)
lambda<-2
target<- -1.5
emax<-solveEmax(target,dose,led50,lambda,e0)
emax

dose1<-solveDose(target,led50,lambda,emax,e0)
dose1

emaxfun(dose=dose1,parm=c(led50,lambda,emax,e0)) - e0

clinDR documentation built on Aug. 9, 2023, 9:08 a.m.