IncrementMin-class: Max increment based on minimum of multiple increment rules

In crmPack: Object-Oriented Implementation of CRM Designs

Max increment based on minimum of multiple increment rules

Description

This class can be used to combine multiple increment rules with the MIN operation.

Details

IncrementsList contains all increment rules, which are again objects of class Increments. The minimum of these individual increments is taken to give the final maximum increment.

Slots

IncrementsList

list of increment rules

Examples

# As example, here we are combining 2 different increment rules. 

# The first rule is the following: 
#      maximum doubling the dose if no DLTs were observed at the current dose
#      or maximum increasing the dose by 1.33 if 1 or 2 DLTs were observed at the current dose
#      or maximum increasing the dose by 1.22 if 3 or more DLTs were observed

# The second rule is the following: 
#   maximum doubling the dose if the current dose is <20
#   OR only maximum increasing the dose by 1.33 if the current dose is >=20


myIncrements1 <- IncrementsRelativeDLT(DLTintervals = c(0, 1, 3),
                                      increments = c(1, 0.33, 0.2))

myIncrements2 <- IncrementsRelative(intervals=c(0, 20),
                                    increments=c(1, 0.33))

# Now we combine the 2 rules
combIncrement <- IncrementMin(IncrementsList=
                                list(myIncrements1,myIncrements2))

crmPack documentation built on June 26, 2024, 5:07 p.m.