IncrementMin-class | R Documentation |
This class can be used to combine multiple increment rules with the MIN operation.
IncrementsList
contains all increment rules, which are again
objects of class Increments
. The minimum of these
individual increments is taken to give the final maximum increment.
IncrementsList
list of increment rules
# As example, here we are combining 2 different increment rules. # The first rule is the following: # maximum doubling the dose if no DLTs were observed at the current dose # or maximum increasing the dose by 1.33 if 1 or 2 DLTs were observed at the current dose # or maximum increasing the dose by 1.22 if 3 or more DLTs were observed # The second rule is the following: # maximum doubling the dose if the current dose is <20 # OR only maximum increasing the dose by 1.33 if the current dose is >=20 myIncrements1 <- IncrementsRelativeDLT(DLTintervals = c(0, 1, 3), increments = c(1, 0.33, 0.2)) myIncrements2 <- IncrementsRelative(intervals=c(0, 20), increments=c(1, 0.33)) # Now we combine the 2 rules combIncrement <- IncrementMin(IncrementsList= list(myIncrements1,myIncrements2))
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