IncrementsRelativeDLT-class: Increments control based on relative differences in terms of...

In crmPack: Object-Oriented Implementation of CRM Designs

Increments control based on relative differences in terms of DLTs

Description

Note that DLTintervals is to be read as follows. If for example, we want to specify three intervals: First 0 DLTs, second 1 or 2 DLTs, and third at least 3 DLTs, then we specify DLTintervals to be c(0, 1, 3). That means, the right bound of the intervals are exclusive to the interval – the vector only gives the left bounds of the intervals. The last interval goes from 3 to infinity.

Slots

DLTintervals

an integer vector with the left bounds of the relevant DLT intervals

increments

a vector of the same length with the maximum allowable relative increments in the DLTintervals

Examples

# As example, here is the rule for: 
#      maximum doubling the dose if no DLTs were observed at the current dose
#      or maximum increasing the dose by 1.33 if 1 or 2 DLTs were observed at the current dose
#      or maximum increasing the dose by 1.22 if 3 or more DLTs were observed

myIncrements <- IncrementsRelativeDLT(DLTintervals = c(0, 1, 3),
                                      increments = c(1, 0.33, 0.2))

crmPack documentation built on Sept. 3, 2022, 1:05 a.m.