IncrementsRelativeParts-class: Increments control based on relative differences in...

In crmPack: Object-Oriented Implementation of CRM Designs

Increments control based on relative differences in intervals, with special rules for part 1 and beginning of part 2

Description

Note that this only works in conjunction with DataParts objects. If the part 2 will just be started in the next cohort, then the next maximum dose will be either dltStart (e.g. -1) shift of the last part 1 dose in case of a DLT in part 1, or cleanStart shift (e.g. 0) in case of no DLTs in part 1. If part 1 will still be on in the next cohort, then the next dose level will be the next higher dose level in the part1Ladder of the data object. If part 2 has been started before, the usual relative increment rules apply, see IncrementsRelative.

Slots

dltStart

integer giving the dose level increment for starting part 2 in case of a DLT in part 1

cleanStart

integer giving the dose level increment for starting part 2 in case of a DLT in part 1. If this is less or equal to 0, then the part 1 ladder will be used to find the maximum next dose. If this is larger than 0, then the relative increment rules will be applied to find the next maximum dose level.

Examples

myIncrements <- IncrementsRelativeParts(dltStart=0,
                                        cleanStart=1)

crmPack documentation built on Sept. 3, 2022, 1:05 a.m.