NextBestNCRM-class: The class with the input for finding the next dose in target...

In crmPack: Object-Oriented Implementation of CRM Designs

The class with the input for finding the next dose in target interval

Description

Note that to avoid numerical problems, the dose selection algorithm has been implemented as follows: First admissible doses are found, which are those with probability to fall in overdose category being below maxOverdoseProb. Next, within the admissible doses, the maximum probability to fall in the target category is calculated. If that is above 5% (i.e., it is not just numerical error), then the corresponding dose is the next recommended dose. Otherwise, the highest admissible dose is the next recommended dose.

Slots

target

the target toxicity interval (limits included)

overdose

the overdose toxicity interval (lower limit excluded, upper limit included)

maxOverdoseProb

maximum overdose probability that is allowed

Examples

# In the example below, the target toxiciy interval [0.2, 0.35] while the 
# overdose interval is (0.35,1]. Finally we would like to constrain the probability
# of overdosing below 25%.
myNextBest <- NextBestNCRM(target=c(0.2, 0.35),
                           overdose=c(0.35, 1),
                           maxOverdoseProb=0.25)

crmPack documentation built on Sept. 3, 2022, 1:05 a.m.