NextBestTD-class: Next best dose based on Pseudo DLE model without sample

In crmPack: Object-Oriented Implementation of CRM Designs

Next best dose based on Pseudo DLE model without sample

Description

The class is to find the next best dose for allocation and the dose for final recommendation at the end of a trial without involving any samples. This is a class for which only DLE response will be incorporated for the dose-allocation. This is only based on the probabilities of the occurrence of a DLE obtained by using the modal estimates of the model paramters. There are two inputs inputs which are the two target probabilities of the occurrence of a DLE used during trial and used at the end of trial, for finding the next best dose for allocation and the dose for recommendation at the end of the trial. It is only suitable to use with the model specified in ModelTox class.

Slots

targetDuringTrial

the target probability of the occurrrence of a DLE to be used during the trial

targetEndOfTrial

the target probability of the occurrence of a DLE to be used at the end of the trial. This target is particularly used to recommend the dose for which its posterior probability of the occurrence of a DLE is equal to this target

Examples

##define the NextBestTD class (no samples and based a pseudo DLE model)
##specified the target probability of the occurrence of a DLE during the trial be 0.35
##specified the target probability of the occurrence of a DLE at the end of trial be 0.3

myNextBest <-NextBestTD(targetDuringTrial=0.35,
                        targetEndOfTrial=0.3)

crmPack documentation built on June 26, 2024, 5:07 p.m.