OpeningMinResponses-class: 'OpeningMinResponses'

In crmPack: Object-Oriented Implementation of Dose Escalation Designs

OpeningMinResponses

Description

OpeningMinResponses opens backfill cohorts when a minimum number of responses has been observed in the trial. The responses can be counted at the cohort's dose level only, or also at lower dose levels if include_lower_doses is set to TRUE.

Usage

OpeningMinResponses(min_responses = 1L, include_lower_doses = FALSE)

.DefaultOpeningMinResponses()

Arguments

min_responses	(count) see slot definition.
include_lower_doses	(logical) see slot definition.

Slots

min_responses

(count)
the minimum number of responses required before backfill cohorts can be opened (at least 1).

include_lower_doses

(logical)
if TRUE, responses at all doses less than or equal to the cohort's dose are counted. If FALSE, only responses at the cohort's dose are counted.

Note

Typically, end users will not use the .DefaultOpeningMinResponses() function.

See Also

Opening and the other subclasses listed in there.

Examples

# Create an OpeningMinResponses object that requires 2 responses
opening <- OpeningMinResponses(min_responses = 2, include_lower_doses = FALSE)

# Display the object
print(opening)

# Create a variant that includes lower doses
opening_inclusive <- OpeningMinResponses(
  min_responses = 2,
  include_lower_doses = TRUE
)
print(opening_inclusive)

crmPack documentation built on July 5, 2026, 9:06 a.m.