StoppingHighestDose-class | R Documentation |
Stop when the highest dose is reached
## for example this can be used in the following way: ## we would like to stop if: ## - next proposed dose is highest dose ## - there are already at least 3 patients on that dose ## - we are sure that this dose is safe, e.g. the ## probability to be in the interval (0%, 20%) of DLT ## rate is above 50%. ## This would be implemented as the following combination: stopHigh <- StoppingHighestDose() & StoppingPatientsNearDose(nPatients=3, percentage=0) & StoppingTargetProb(target=c(0, 0.2), prob=0.5) ## of course this rule would then need to be combined ## with the other standard rules for when to stop ## when the MTD is found based on being near ## e.g. a 30% DLT probability or having reached maximal sample ## size, in the manner of: ## stopRule <- stopHigh | stopLow | stopSamplesize
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