Stop based on probability of target biomarker
the biomarker target range, that
needs to be reached. For example, (0.8, 1.0) and
means we target a dose with at least 80% of maximum biomarker level.
relative (default, then the
target is interpreted
relative to the maximum, so must be a probability range) or
target is interpreted as absolute biomarker range)
required target probability for reaching sufficient precision
# As example, here is the rule for: # stopping the study if there is at least 0.5 probability that the biomarker # (efficacy) is within the biomarker target range of [0.9, 1.0] (relative to the # maximum for the biomarker). myStopping <- StoppingTargetBiomarker(target = c(0.9, 1), prob = 0.5)
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