StoppingTargetBiomarker-class: Stop based on probability of target biomarker

In crmPack: Object-Oriented Implementation of CRM Designs

Stop based on probability of target biomarker

Description

Stop based on probability of target biomarker

Slots

target

the biomarker target range, that needs to be reached. For example, (0.8, 1.0) and scale="relative" means we target a dose with at least 80% of maximum biomarker level.

scale

either relative (default, then the target is interpreted relative to the maximum, so must be a probability range) or absolute (then the target is interpreted as absolute biomarker range)

prob

required target probability for reaching sufficient precision

Examples

# As example, here is the rule for: 
#   stopping the study if there is at least 0.5 probability that the biomarker 
#   (efficacy) is within the biomarker target range of [0.9, 1.0] (relative to the
#   maximum for the biomarker).

myStopping <- StoppingTargetBiomarker(target = c(0.9, 1),
                                      prob = 0.5)

crmPack documentation built on June 26, 2024, 5:07 p.m.