minnow_sd: A fitted GUTS-RED-SD scenario of the fathead minnow

In cvasi: Calibration, Validation, and Simulation of TKTD Models

A fitted GUTS-RED-SD scenario of the fathead minnow

Description

The example scenario consists of a fitted GUTS-RED-SD model and a constant exposure series. Model parameters were derived from a typical four-day acute fish toxicity study of the fathead minnow by Geiger et al. (1988). The study evaluated the effect of chlorpyrifos concentrations in water on survival of fathead minnows.

Usage

minnow_sd

Format

An object of class GutsRedSd of length 1.

Details

The toxicity dataset used for parameter calibration is also referred to as GUTS Ring-test dataset C by EFSA (2018). Fitted parameters were estimated using the morse package.

The exposure series of the example scenario is a constant concentration of 1.0 µmol/L over a period of four days with a daily time step.

Source

https://mosaic.univ-lyon1.fr/guts

References

Geiger D.L., Call D.J., and Brooke L.T., 1988: Acute toxicities of organic chemicals to fathead minnows (Pimephales promelas): Volume IV, pp. 195-197. University of Wisconsin-Superior, Center for Lake Superior Environmental Studies. ISBN 9780961496838.

EFSA PPR Panel (EFSA Panel on Plant Protection Products and their Residues), Ockleford C, Adriaanse P, Berny P, et al., 2018: Scientific Opinion on the state of the art of Toxicokinetic/Toxicodynamic (TKTD) effect models for regulatory risk assessment of pesticides for aquatic organisms. EFSA Journal 2018; 16(8):5377, 188 pp. \Sexpr[results=rd]{tools:::Rd_expr_doi("10.2903/j.efsa.2018.5377")}

See Also

GUTS-RED-models

Examples

# Print scenario parameters
minnow_sd

# Run the example scenario
minnow_sd %>% simulate()

cvasi documentation built on Sept. 11, 2025, 5:11 p.m.