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R/data.R
In cvasi: Calibration, Validation, and Simulation of TKTD Models
#' A fitted GUTS-RED-SD scenario of the fathead minnow
#'
#' The example scenario consists of a fitted [GUTS-RED-SD][GUTS_RED_SD]
#' model and a constant exposure series. Model parameters were derived from a
#' typical four-day acute fish toxicity study of the *fathead minnow* by
#' Geiger *et al.* (1988).
#' The study evaluated the effect of *chlorpyrifos* concentrations in water on
#' survival of *fathead minnows*.
#'
#' The toxicity dataset used for parameter calibration is also referred to as
#' *GUTS Ring-test dataset C* by EFSA (2018). Fitted parameters were estimated
#' using the *morse* package.
#'
#' The exposure series of the example scenario is a constant concentration of 1.0 µmol/L
#' over a period of four days with a daily time step.
#'
#' @seealso [GUTS-RED-models]
#' @references
#' Geiger D.L., Call D.J., and Brooke L.T., 1988: *Acute toxicities of organic
#' chemicals to fathead minnows (Pimephales promelas): Volume IV*, pp. 195-197.
#' University of Wisconsin-Superior, Center for Lake Superior Environmental Studies.
#' ISBN 9780961496838.
#'
#' EFSA PPR Panel (EFSA Panel on Plant Protection Products and their Residues),
#' Ockleford C, Adriaanse P, Berny P, et al., 2018: *Scientific Opinion on the
#' state of the art of Toxicokinetic/Toxicodynamic (TKTD) effect models for
#' regulatory risk assessment of pesticides for aquatic organisms*. EFSA Journal 2018;
#' 16(8):5377, 188 pp. \doi{10.2903/j.efsa.2018.5377}
#'
#' @source https://mosaic.univ-lyon1.fr/guts
#' @examples
#' # Print scenario parameters
#' minnow_sd
#'
#' # Run the example scenario
#' minnow_sd %>% simulate()
"minnow_sd"
#' A fitted GUTS-RED-IT scenario of the fathead minnow
#'
#' The example scenario consists of a fitted [GUTS-RED-IT][GUTS_RED_IT]
#' model and a constant exposure series. Model parameters were derived from a
#' typical four-day acute fish toxicity study of the *fathead minnow* by
#' Geiger *et al.* (1988).
#' The study evaluated the effect of *chlorpyrifos* concentrations in water on
#' survival of *fathead minnows*.
#'
#' The toxicity dataset used for parameter calibration is also referred to as
#' *GUTS Ring-test dataset C* by EFSA (2018). Fitted parameters were estimated
#' using the *morse* package.
#'
#' The exposure series of the example scenario is a constant concentration of 1.0 µmol/L
#' over a period of four days with a daily time step.
#'
#' @seealso [GUTS-RED-models]
#' @references
#' Geiger D.L., Call D.J., and Brooke L.T., 1988: *Acute toxicities of organic
#' chemicals to fathead minnows (Pimephales promelas): Volume IV*, pp. 195-197.
#' University of Wisconsin-Superior, Center for Lake Superior Environmental Studies.
#' ISBN 9780961496838.
#'
#' EFSA PPR Panel (EFSA Panel on Plant Protection Products and their Residues),
#' Ockleford C, Adriaanse P, Berny P, et al., 2018: *Scientific Opinion on the
#' state of the art of Toxicokinetic/Toxicodynamic (TKTD) effect models for
#' regulatory risk assessment of pesticides for aquatic organisms*. EFSA Journal 2018;
#' 16(8):5377, 188 pp. \doi{10.2903/j.efsa.2018.5377}
#'
#' @source https://mosaic.univ-lyon1.fr/guts
#' @examples
#' # Print scenario parameters
#' minnow_it
#'
#' # Run the example scenario
#' minnow_it %>% simulate()
#'
"minnow_it"
#' Lemna model fitted to *metsulfuron* effect data
#'
#' Data set for the parametrisation of a mechanistic combined
#' toxicokinetic-toxicodynamic (TK/TD) and growth model for the aquatic
#' macrophytes Lemna spp. as published by Schmitt *et al.* (2013).
#' The growth model was parameterised by Schmitt et al. based on these
#' data while toxicokinetic and toxicodynamic parameters were determined by
#' fitting the model using substance specific effect data of the
#' herbicide *metsulfuron-methyl*.
#'
#' The scenario is based on the [Lemna_Schmitt] model.
#'
#' @seealso [Lemna-models], [schmitt2013]
#' @references
#' Schmitt W., Bruns E., Dollinger M., and Sowig P., 2013: *Mechanistic TK/TD-model
#' simulating the effect of growth inhibitors on Lemna populations*. Ecol Model 255,
#' pp. 1-10. \doi{10.1016/j.ecolmodel.2013.01.017}
"metsulfuron"
#' A Lemna_SETAC scenario with variable environment
#'
#' A mechanistic combined toxicokinetic-toxicodynamic (TK/TD) and growth
#' model for the aquatic macrophytes Lemna spp. as published by
#' Klein *et al.* (2021).
#'
#' The scenario will simulate a period of 365 days, a start
#' population of 80 g/m² dry weight, variable environmental conditions, and a
#' complex, time-varying exposure pattern.
#'
#' The scenario setup was published by Hommen *et al*. (2015). Exposure pattern
#' and substance specific parameters are of exemplary character
#' and represent the herbicide *metsulfuron-methyl*. The parameters were
#' derived by Schmitt et al. (2013) based on literature
#' data.
#'
#' @seealso [Lemna-models]
#' @references
#' Hommen U., Schmitt W., Heine S., Brock Theo CM., Duquesne S., Manson P., Meregalli G.,
#' Ochoa-Acuña H., van Vliet P., Arts G., 2015: How TK-TD and Population Models for
#' Aquatic Macrophytes Could Support the Risk Assessment for Plant Protection
#' Products. Integr Environ Assess Manag 12(1), pp. 82-95.
#' \doi{10.1002/ieam.1715}
#'
#' Klein J., Cedergreen N., Heine S., Reichenberger S., Rendal C.,
#' Schmitt W., Hommen U., 2021: Refined description of the *Lemna* TKTD growth model
#' based on *Schmitt et al.* (2013) - equation system and default parameters.
#' Report of the working group *Lemna* of the SETAC Europe Interest Group Effect
#' Modeling. Version 1.1, uploaded on 09 May 2022.
#' <https://www.setac.org/group/effect-modeling.html>
#'
#' Schmitt W., Bruns E., Dollinger M., Sowig P., 2013: Mechanistic TK/TD-model
#' simulating the effect of growth inhibitors on *Lemna* populations. Ecol Model
#' 255, pp. 1-10. \doi{10.1016/j.ecolmodel.2013.01.017}
#'
#' @examples
#' # Simulate the example scenario
#' focusd1 %>% simulate()
#'
"focusd1"
#' A DEB abj scenario of Americamysis bahia
#'
#' Species parameters were collected from the AddMyPet database entry on
#' Americamysis bahia (Opossum shrimp). The exposure series consists of a
#' constant exposure resulting in medium effects on length and reproduction.
#'
#' @seealso [DEB_abj()]
#' @source <https://www.bio.vu.nl/thb/deb/deblab/add_my_pet/entries_web/Americamysis_bahia/Americamysis_bahia_res.html>
#'
"americamysis"
#' A DEBtox scenario of Daphnia magna
#'
#' Species and substance parameters were collected from test runs of the
#' original [DEBtox] Daphnia model.
#'
#' @seealso [DEBtox()]
"dmagna"
#' A Lemna effect study data set with multiple treatment levels
#'
#' Data was collected from Schmitt et al. (2013). The study observed the number of
#' Lemna fronds during the study period of 14 days. The organisms were exposed
#' to multiple concentrations of the sulfonyl urea herbicide *metsulfuron-methyl*.
#'
#' The number of Lemna fronds was recorded at the beginning of the experiment (t=0)
#' and after 3, 5, 7, 10, 12, and 14 days. The exposure to *metsulfuron-methyl*
#' was only present during the first seven days, which was followed by a recovery
#' period of another seven days without exposure to the substance.
#'
#' The tabular dataset consists of four columns:
#'
#' - First column: time (days)
#' - Second column: observed number of fronds (-)
#' - Third column: trial id (-)
#' - Fourth column: metsulfuron-methyl concentration (ug/L)
#'
#' An example [scenario] with parameters fitted to the experimental data set
#' as conducted by Schmitt et al. is available as [`metsulfuron`].
#'
#' @seealso [Lemna-models], [metsulfuron]
#' @references
#' Schmitt W., Bruns E., Dollinger M., and Sowig P., 2013: *Mechanistic TK/TD-model
#' simulating the effect of growth inhibitors on Lemna populations*. Ecol Model 255,
#' pp. 1-10. \doi{10.1016/j.ecolmodel.2013.01.017}
"schmitt2013"
#' A Weber scenario of algae exposed to isoproturon
#'
#' The scenario recreates the conditions of algae species *R. subcapitata* exposed
#' to isoproturon in a flow-through reactor experiment, see Weber et al. (2012)
#' publication. Scenario parameters and exposure series were set according to
#' reported values to represent conditions in reactor A, as depicted in
#' Figure 4A in Weber et al.
#'
#' @seealso [Algae_Weber]
#' @references
#' Weber D, Schaefer D, Dorgerloh M, Bruns E, Goerlitz G, Hammel K, Preuss TG
#' and Ratte HT, 2012. Combination of a higher-tier flow-through system and
#' population modeling to assess the effects of time-variable exposure of
#' isoproturon on the green algae Desmodesmus subspictatus and
#' Pseudokirchneriella subcapitata. Environmental Toxicology and
#' Chemistry, 31, 899-908. \doi{10.1002/etc.1765}
"rsubcapitata"
#' EFSA Ringtest Dataset C
#'
#' This dataset is part of EFSA's *GUTS* ringtest to compare results from software
#' implementations of [GUTS-RED models][GUTS-RED-models] (EFSA 2018). The ringtest
#' focused on [GUTS-RED-IT][GUTS_RED_IT] and [GUTS-RED-SD][GUTS_RED_SD] models.
#'
#' *Dataset C* in this ringtest came from the work of Geiger et al. (1988) on effects of
#' *Diazinon* on *fathead minnow*. The dataset contains four columns, identifying the control
#' and treatment levels, the concentrations in these treatments, the timepoint of measurement
#' and the number of survivors.
#'
#' @seealso [GUTS-RED-models]
#' @references
#' EFSA PPR Panel (EFSA Panel on Plant Protection Products and their Residues),
#' Ockleford C, Adriaanse P, Berny P, et al., 2018: *Scientific Opinion on the
#' state of the art of Toxicokinetic/Toxicodynamic (TKTD) effect models for
#' regulatory risk assessment of pesticides for aquatic organisms*. EFSA Journal 2018;
#' 16(8):5377, 188 pp. \doi{10.2903/j.efsa.2018.5377}
#'
#' Geiger DL, Call DJ, and Brooke LT, 1988: Acute Toxicities of Organic Chemicals to
#' Fathead Minnow (*Pimephales promelas*), Vol IV. Center for Lake Superior Environmental
#' Studies, University of Wisconsin-Superior, Superior, WI, USA.
#'
#' https://cran.r-project.org/web/packages/GUTS/vignettes/ringTest.html
"ringtest_c"
#' EFSA Ringtest Dataset A SD
#'
#' This dataset is part of EFSA's *GUTS* ringtest to compare results from software
#' implementations of [GUTS-RED models][GUTS-RED-models] (EFSA 2018). The ringtest
#' focused on [GUTS-RED-IT][GUTS_RED_IT] and [GUTS-RED-SD][GUTS_RED_SD] models.
#'
#' *Dataset A SD* for the GUTS ring test is a Hypothetical data set constructed with SD.
#'
#' @seealso [GUTS-RED-models]
#' @references
#' EFSA PPR Panel (EFSA Panel on Plant Protection Products and their Residues),
#' Ockleford C, Adriaanse P, Berny P, et al., 2018: *Scientific Opinion on the
#' state of the art of Toxicokinetic/Toxicodynamic (TKTD) effect models for
#' regulatory risk assessment of pesticides for aquatic organisms*. EFSA Journal 2018;
#' 16(8):5377, 188 pp. \doi{10.2903/j.efsa.2018.5377}
#'
#'
#' https://cran.r-project.org/web/packages/GUTS/vignettes/ringTest.html
"ringtest_sd"
#' EFSA Ringtest Dataset A SD
#'
#' This dataset is part of EFSA's *GUTS* ringtest to compare results from software
#' implementations of [GUTS-RED models][GUTS-RED-models] (EFSA 2018). The ringtest
#' focused on [GUTS-RED-IT][GUTS_RED_IT] and [GUTS-RED-SD][GUTS_RED_SD] models.
#'
#' *Dataset A IT* for the GUTS ring test is a Hypothetical data set constructed with IT.
#'
#' @seealso [GUTS-RED-models]
#' @references
#' EFSA PPR Panel (EFSA Panel on Plant Protection Products and their Residues),
#' Ockleford C, Adriaanse P, Berny P, et al., 2018: *Scientific Opinion on the
#' state of the art of Toxicokinetic/Toxicodynamic (TKTD) effect models for
#' regulatory risk assessment of pesticides for aquatic organisms*. EFSA Journal 2018;
#' 16(8):5377, 188 pp. \doi{10.2903/j.efsa.2018.5377}
#'
#'
#' https://cran.r-project.org/web/packages/GUTS/vignettes/ringTest.html
"ringtest_it"
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#' A fitted GUTS-RED-SD scenario of the fathead minnow
#'
#' The example scenario consists of a fitted [GUTS-RED-SD][GUTS_RED_SD]
#' model and a constant exposure series. Model parameters were derived from a
#' typical four-day acute fish toxicity study of the *fathead minnow* by
#' Geiger *et al.* (1988).
#' The study evaluated the effect of *chlorpyrifos* concentrations in water on
#' survival of *fathead minnows*.
#'
#' The toxicity dataset used for parameter calibration is also referred to as
#' *GUTS Ring-test dataset C* by EFSA (2018). Fitted parameters were estimated
#' using the *morse* package.
#'
#' The exposure series of the example scenario is a constant concentration of 1.0 µmol/L
#' over a period of four days with a daily time step.
#'
#' @seealso [GUTS-RED-models]
#' @references
#' Geiger D.L., Call D.J., and Brooke L.T., 1988: *Acute toxicities of organic
#' chemicals to fathead minnows (Pimephales promelas): Volume IV*, pp. 195-197.
#' University of Wisconsin-Superior, Center for Lake Superior Environmental Studies.
#' ISBN 9780961496838.
#'
#' EFSA PPR Panel (EFSA Panel on Plant Protection Products and their Residues),
#' Ockleford C, Adriaanse P, Berny P, et al., 2018: *Scientific Opinion on the
#' state of the art of Toxicokinetic/Toxicodynamic (TKTD) effect models for
#' regulatory risk assessment of pesticides for aquatic organisms*. EFSA Journal 2018;
#' 16(8):5377, 188 pp. \doi{10.2903/j.efsa.2018.5377}
#'
#' @source https://mosaic.univ-lyon1.fr/guts
#' @examples
#' # Print scenario parameters
#' minnow_sd
#'
#' # Run the example scenario
#' minnow_sd %>% simulate()
"minnow_sd"
#' A fitted GUTS-RED-IT scenario of the fathead minnow
#'
#' The example scenario consists of a fitted [GUTS-RED-IT][GUTS_RED_IT]
#' model and a constant exposure series. Model parameters were derived from a
#' typical four-day acute fish toxicity study of the *fathead minnow* by
#' Geiger *et al.* (1988).
#' The study evaluated the effect of *chlorpyrifos* concentrations in water on
#' survival of *fathead minnows*.
#'
#' The toxicity dataset used for parameter calibration is also referred to as
#' *GUTS Ring-test dataset C* by EFSA (2018). Fitted parameters were estimated
#' using the *morse* package.
#'
#' The exposure series of the example scenario is a constant concentration of 1.0 µmol/L
#' over a period of four days with a daily time step.
#'
#' @seealso [GUTS-RED-models]
#' @references
#' Geiger D.L., Call D.J., and Brooke L.T., 1988: *Acute toxicities of organic
#' chemicals to fathead minnows (Pimephales promelas): Volume IV*, pp. 195-197.
#' University of Wisconsin-Superior, Center for Lake Superior Environmental Studies.
#' ISBN 9780961496838.
#'
#' EFSA PPR Panel (EFSA Panel on Plant Protection Products and their Residues),
#' Ockleford C, Adriaanse P, Berny P, et al., 2018: *Scientific Opinion on the
#' state of the art of Toxicokinetic/Toxicodynamic (TKTD) effect models for
#' regulatory risk assessment of pesticides for aquatic organisms*. EFSA Journal 2018;
#' 16(8):5377, 188 pp. \doi{10.2903/j.efsa.2018.5377}
#'
#' @source https://mosaic.univ-lyon1.fr/guts
#' @examples
#' # Print scenario parameters
#' minnow_it
#'
#' # Run the example scenario
#' minnow_it %>% simulate()
#'
"minnow_it"
#' Lemna model fitted to *metsulfuron* effect data
#'
#' Data set for the parametrisation of a mechanistic combined
#' toxicokinetic-toxicodynamic (TK/TD) and growth model for the aquatic
#' macrophytes Lemna spp. as published by Schmitt *et al.* (2013).
#' The growth model was parameterised by Schmitt et al. based on these
#' data while toxicokinetic and toxicodynamic parameters were determined by
#' fitting the model using substance specific effect data of the
#' herbicide *metsulfuron-methyl*.
#'
#' The scenario is based on the [Lemna_Schmitt] model.
#'
#' @seealso [Lemna-models], [schmitt2013]
#' @references
#' Schmitt W., Bruns E., Dollinger M., and Sowig P., 2013: *Mechanistic TK/TD-model
#' simulating the effect of growth inhibitors on Lemna populations*. Ecol Model 255,
#' pp. 1-10. \doi{10.1016/j.ecolmodel.2013.01.017}
"metsulfuron"
#' A Lemna_SETAC scenario with variable environment
#'
#' A mechanistic combined toxicokinetic-toxicodynamic (TK/TD) and growth
#' model for the aquatic macrophytes Lemna spp. as published by
#' Klein *et al.* (2021).
#'
#' The scenario will simulate a period of 365 days, a start
#' population of 80 g/m² dry weight, variable environmental conditions, and a
#' complex, time-varying exposure pattern.
#'
#' The scenario setup was published by Hommen *et al*. (2015). Exposure pattern
#' and substance specific parameters are of exemplary character
#' and represent the herbicide *metsulfuron-methyl*. The parameters were
#' derived by Schmitt et al. (2013) based on literature
#' data.
#'
#' @seealso [Lemna-models]
#' @references
#' Hommen U., Schmitt W., Heine S., Brock Theo CM., Duquesne S., Manson P., Meregalli G.,
#' Ochoa-Acuña H., van Vliet P., Arts G., 2015: How TK-TD and Population Models for
#' Aquatic Macrophytes Could Support the Risk Assessment for Plant Protection
#' Products. Integr Environ Assess Manag 12(1), pp. 82-95.
#' \doi{10.1002/ieam.1715}
#'
#' Klein J., Cedergreen N., Heine S., Reichenberger S., Rendal C.,
#' Schmitt W., Hommen U., 2021: Refined description of the *Lemna* TKTD growth model
#' based on *Schmitt et al.* (2013) - equation system and default parameters.
#' Report of the working group *Lemna* of the SETAC Europe Interest Group Effect
#' Modeling. Version 1.1, uploaded on 09 May 2022.
#' <https://www.setac.org/group/effect-modeling.html>
#'
#' Schmitt W., Bruns E., Dollinger M., Sowig P., 2013: Mechanistic TK/TD-model
#' simulating the effect of growth inhibitors on *Lemna* populations. Ecol Model
#' 255, pp. 1-10. \doi{10.1016/j.ecolmodel.2013.01.017}
#'
#' @examples
#' # Simulate the example scenario
#' focusd1 %>% simulate()
#'
"focusd1"
#' A DEB abj scenario of Americamysis bahia
#'
#' Species parameters were collected from the AddMyPet database entry on
#' Americamysis bahia (Opossum shrimp). The exposure series consists of a
#' constant exposure resulting in medium effects on length and reproduction.
#'
#' @seealso [DEB_abj()]
#' @source <https://www.bio.vu.nl/thb/deb/deblab/add_my_pet/entries_web/Americamysis_bahia/Americamysis_bahia_res.html>
#'
"americamysis"
#' A DEBtox scenario of Daphnia magna
#'
#' Species and substance parameters were collected from test runs of the
#' original [DEBtox] Daphnia model.
#'
#' @seealso [DEBtox()]
"dmagna"
#' A Lemna effect study data set with multiple treatment levels
#'
#' Data was collected from Schmitt et al. (2013). The study observed the number of
#' Lemna fronds during the study period of 14 days. The organisms were exposed
#' to multiple concentrations of the sulfonyl urea herbicide *metsulfuron-methyl*.
#'
#' The number of Lemna fronds was recorded at the beginning of the experiment (t=0)
#' and after 3, 5, 7, 10, 12, and 14 days. The exposure to *metsulfuron-methyl*
#' was only present during the first seven days, which was followed by a recovery
#' period of another seven days without exposure to the substance.
#'
#' The tabular dataset consists of four columns:
#'
#' - First column: time (days)
#' - Second column: observed number of fronds (-)
#' - Third column: trial id (-)
#' - Fourth column: metsulfuron-methyl concentration (ug/L)
#'
#' An example [scenario] with parameters fitted to the experimental data set
#' as conducted by Schmitt et al. is available as [`metsulfuron`].
#'
#' @seealso [Lemna-models], [metsulfuron]
#' @references
#' Schmitt W., Bruns E., Dollinger M., and Sowig P., 2013: *Mechanistic TK/TD-model
#' simulating the effect of growth inhibitors on Lemna populations*. Ecol Model 255,
#' pp. 1-10. \doi{10.1016/j.ecolmodel.2013.01.017}
"schmitt2013"
#' A Weber scenario of algae exposed to isoproturon
#'
#' The scenario recreates the conditions of algae species *R. subcapitata* exposed
#' to isoproturon in a flow-through reactor experiment, see Weber et al. (2012)
#' publication. Scenario parameters and exposure series were set according to
#' reported values to represent conditions in reactor A, as depicted in
#' Figure 4A in Weber et al.
#'
#' @seealso [Algae_Weber]
#' @references
#' Weber D, Schaefer D, Dorgerloh M, Bruns E, Goerlitz G, Hammel K, Preuss TG
#' and Ratte HT, 2012. Combination of a higher-tier flow-through system and
#' population modeling to assess the effects of time-variable exposure of
#' isoproturon on the green algae Desmodesmus subspictatus and
#' Pseudokirchneriella subcapitata. Environmental Toxicology and
#' Chemistry, 31, 899-908. \doi{10.1002/etc.1765}
"rsubcapitata"
#' EFSA Ringtest Dataset C
#'
#' This dataset is part of EFSA's *GUTS* ringtest to compare results from software
#' implementations of [GUTS-RED models][GUTS-RED-models] (EFSA 2018). The ringtest
#' focused on [GUTS-RED-IT][GUTS_RED_IT] and [GUTS-RED-SD][GUTS_RED_SD] models.
#'
#' *Dataset C* in this ringtest came from the work of Geiger et al. (1988) on effects of
#' *Diazinon* on *fathead minnow*. The dataset contains four columns, identifying the control
#' and treatment levels, the concentrations in these treatments, the timepoint of measurement
#' and the number of survivors.
#'
#' @seealso [GUTS-RED-models]
#' @references
#' EFSA PPR Panel (EFSA Panel on Plant Protection Products and their Residues),
#' Ockleford C, Adriaanse P, Berny P, et al., 2018: *Scientific Opinion on the
#' state of the art of Toxicokinetic/Toxicodynamic (TKTD) effect models for
#' regulatory risk assessment of pesticides for aquatic organisms*. EFSA Journal 2018;
#' 16(8):5377, 188 pp. \doi{10.2903/j.efsa.2018.5377}
#'
#' Geiger DL, Call DJ, and Brooke LT, 1988: Acute Toxicities of Organic Chemicals to
#' Fathead Minnow (*Pimephales promelas*), Vol IV. Center for Lake Superior Environmental
#' Studies, University of Wisconsin-Superior, Superior, WI, USA.
#'
#' https://cran.r-project.org/web/packages/GUTS/vignettes/ringTest.html
"ringtest_c"
#' EFSA Ringtest Dataset A SD
#'
#' This dataset is part of EFSA's *GUTS* ringtest to compare results from software
#' implementations of [GUTS-RED models][GUTS-RED-models] (EFSA 2018). The ringtest
#' focused on [GUTS-RED-IT][GUTS_RED_IT] and [GUTS-RED-SD][GUTS_RED_SD] models.
#'
#' *Dataset A SD* for the GUTS ring test is a Hypothetical data set constructed with SD.
#'
#' @seealso [GUTS-RED-models]
#' @references
#' EFSA PPR Panel (EFSA Panel on Plant Protection Products and their Residues),
#' Ockleford C, Adriaanse P, Berny P, et al., 2018: *Scientific Opinion on the
#' state of the art of Toxicokinetic/Toxicodynamic (TKTD) effect models for
#' regulatory risk assessment of pesticides for aquatic organisms*. EFSA Journal 2018;
#' 16(8):5377, 188 pp. \doi{10.2903/j.efsa.2018.5377}
#'
#'
#' https://cran.r-project.org/web/packages/GUTS/vignettes/ringTest.html
"ringtest_sd"
#' EFSA Ringtest Dataset A SD
#'
#' This dataset is part of EFSA's *GUTS* ringtest to compare results from software
#' implementations of [GUTS-RED models][GUTS-RED-models] (EFSA 2018). The ringtest
#' focused on [GUTS-RED-IT][GUTS_RED_IT] and [GUTS-RED-SD][GUTS_RED_SD] models.
#'
#' *Dataset A IT* for the GUTS ring test is a Hypothetical data set constructed with IT.
#'
#' @seealso [GUTS-RED-models]
#' @references
#' EFSA PPR Panel (EFSA Panel on Plant Protection Products and their Residues),
#' Ockleford C, Adriaanse P, Berny P, et al., 2018: *Scientific Opinion on the
#' state of the art of Toxicokinetic/Toxicodynamic (TKTD) effect models for
#' regulatory risk assessment of pesticides for aquatic organisms*. EFSA Journal 2018;
#' 16(8):5377, 188 pp. \doi{10.2903/j.efsa.2018.5377}
#'
#'
#' https://cran.r-project.org/web/packages/GUTS/vignettes/ringTest.html
"ringtest_it"
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