dip7: Parameter estimates of Weibull fit to individual dissolution...
In disprofas: Non-Parametric Dissolution Profile Analysis

dip7	R Documentation

Parameter estimates of Weibull fit to individual dissolution profiles

Description

A data set containing the Weibull parameter estimates obtained from fitting Weibull curves to the cumulative dissolution profiles of individual tablets of three reference batches and one test batch, n = 12 tablets each. The Weibull curve is fitted according to the formula x(t) = x_{max} ( 1 - exp(- \alpha t^{\beta})), where x(t) is the percent released at time t divided by 100, x_{max} is the maximal release (set to be 100, i.e. assumed to be a constant).

Usage

data(dip7)

Format

A data frame with 48 observations and 5 variables:

tablet: Factor with levels 1 to 12 representing individual tablets
batch: Factor with levels b0, b1, b2, b3 and b4
type: Factor with levels ref (Reference) and test (Test)
alpha: Weibull parameter \alpha, i.e. the scale parameter being a function of the undissolved proportion at t = 1
beta: Weibull parameter \beta, i.e. the shape parameter which is related to the dissolution rate per unit of time

Source

See reference: Example data set shown in Table 4.

References

Tsong, Y., Hammerstrom, T., Chen, J.J. Multipoint dissolution specification and acceptance sampling rule based on profile modeling and principal component analysis. J Biopharm Stat. 1997; 7(3): 423-439.
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