dip8: Parameter estimates of Weibull fit to individual dissolution...
In disprofas: Non-Parametric Dissolution Profile Analysis

dip8	R Documentation

Parameter estimates of Weibull fit to individual dissolution profiles

Description

A data set containing the Weibull parameter estimates obtained from fitting Weibull curves to the cumulative dissolution profiles of individual tablets of one reference batch and one test or post-change batch with a minor modification and a second test or post-change batch with a major modification, n = 12 tablets each.

Usage

data(dip8)

Format

A data frame with 36 observations and 4 variables:

tablet: Factor with levels 1 to 12 representing individual tablets
type: Factor with levels ref (Reference), minor (Test) and major (Test)
alpha: Weibull parameter \alpha, i.e. the scale parameter being a function of the undissolved proportion at t = 1
beta: Weibull parameter \beta, i.e. the shape parameter which is related to the dissolution rate per unit of time

Source

See reference: Example data set shown in Table III.

References

Sathe, P.M., Tsong, Y., and Shah, V.P. In-Vitro dissolution profile comparison: Statistics and analysis, model dependent approach. Pharm Res. 1996; 13(12): 1799-1803.
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