Description Usage Arguments Value Examples
The generated disease model is the list of effect size coefficients.
The list comprises the following fields: 'syner', 'marg' and 'inter'.
'syner' is itself a list of numeric vectors with two entries named
'A0' and 'A1'. 'A0' refers to the vector of effect sizes when the target
variant A = 0. Similarly, 'A1' refers to the vector of effect
sizes in the case A = 1. The two other entries 'marg' and
'inter' are, respectively, the marginal and epistatic effect sizes. The
effect sizes are independent and normally-distributed. The mean
parameter is either a list of vectors or a vector of length 4. If
mean
is a vector, then the effect sizes for each type of effects have
the same mean. Otherwise, the corresponding vector in the list
specifies their individual means. The same logic applies to sd
, the
standard deviation parameter. For coherence, the parameters mean
and
sd
are encoded in the same order as the output.
1 |
nX |
number of SNPs interacting with the target variant |
nY |
number of SNPs with marginal effects |
nZ12 |
number of SNP pairs with epistatic effects |
mean |
vector or list of means |
sd |
vector or list of standard deviations |
a list of vectors corresponding to the effect size coefficients.
1 2 |
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