dose_admissible: Is each dose admissible?

In escalation: A Modular Approach to Dose-Finding Clinical Trials

Is each dose admissible?

Description

Get a vector of logical values reflecting whether each dose is admissible. Admissibility is defined in different ways for different models, and may not be defined at all in some models. For instance, in the TPI method, doses are inadmissible when the posterior probability is high that the toxicity rate exceeds the target value. In contrast, admissibility is not defined in the general CRM model (but it can be added with auxiliary classes). In this latter case, doses are implicitly considered to be admissible, by default.

Usage

dose_admissible(x, ...)

Arguments

x	Object of class selector
...	arguments passed to other methods

Value

a logical vector

Examples

outcomes <- '1NNN 2TTT'

# TPI example. This method defines admissibility.
fit1 <- get_tpi(num_doses = 5, target = 0.3, k1 = 1, k2 = 1.5,
                exclusion_certainty = 0.95) %>%
  fit(outcomes)
fit1 %>% dose_admissible()

# Ordinary CRM example with no admissibility function.
skeleton <- c(0.05, 0.1, 0.25, 0.4, 0.6)
target <- 0.25
fit2 <- get_dfcrm(skeleton = skeleton, target = target) %>%
  fit(outcomes)
fit2 %>% dose_admissible()

# Same CRM example with added admissibility function
fit3 <- get_dfcrm(skeleton = skeleton, target = target) %>%
  stop_when_too_toxic(dose = 1, tox_threshold = target, confidence = 0.8) %>%
  fit(outcomes)
fit3 %>% dose_admissible()

escalation documentation built on June 27, 2024, 5:09 p.m.