enforce_three_plus_three: Enforce that a trial path has followed the 3+3 method.

In escalation: A Modular Approach to Dose-Finding Clinical Trials

Enforce that a trial path has followed the 3+3 method.

Description

This function stops with en error if it detects that outcomes describing a trial path have diverged from that advocated by the 3+3 method.

Usage

enforce_three_plus_three(outcomes, allow_deescalate = FALSE)

Arguments

outcomes	Outcomes observed. See parse_phase1_outcomes.
allow_deescalate	TRUE to allow de-escalation, as described by Korn et al. Default is FALSE.

Value

Nothing. Function stops if problem detected.

Examples

## Not run: 
enforce_three_plus_three('1NNN 2NTN 2NNN')  # OK
enforce_three_plus_three('1NNN 2NTN 2N')  # OK too, albeit in-progress cohort
enforce_three_plus_three('1NNN 1N')  # Not OK because should have escalated

## End(Not run)

escalation documentation built on June 27, 2024, 5:09 p.m.