Description Usage Arguments Value Examples
View source: R/operating_characteristics.R
Calculate the percent of doses which are inside the optimal MTD interval [true_MTD -
margin ; true_MTD + margin]
.
1 | optimal_mtd(dose_matrix, true_mtd, margin, digits = 2)
|
dose_matrix |
a numerical matrix or vector of assigned doses for each step of the trial (column) and for each trial (row). |
true_mtd |
a numerical value of the true Maximum Tolerable Dose. |
margin |
a numerical value of the acceptable margin of distance from the
|
digits |
a numerical value indicating the number of digits. |
interval
the average percent of doses which are inside the optimal MTD interval.
underdose
the average percent of doses which are smaller than the lower limit of the optimal MTD interval.
overdose
the average percent of doses which are greater than the upper limit of the optimal MTD interval.
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 | ## Not run:
DLT <- 0
dose <- 20
step_zero <- ewoc_d1classical(DLT ~ dose, type = 'discrete',
theta = 0.33, alpha = 0.25,
min_dose = 0, max_dose = 100,
dose_set = seq(0, 100, 20),
rho_prior = matrix(1, ncol = 2, nrow = 1),
mtd_prior = matrix(1, ncol = 2, nrow = 1),
rounding = "nearest")
response_sim <- response_d1classical(rho = 0.05, mtd = 20, theta = 0.33,
min_dose = 10, max_dose = 50)
sim <- ewoc_simulation(step_zero = step_zero,
n_sim = 2, sample_size = 30,
alpha_strategy = "increasing",
response_sim = response_sim,
ncores = 2)
optimal_mtd(sim$mtd_sim, true_mtd = 20, margin = 0.1*20)
optimal_mtd(sim$dose_sim, true_mtd = 20, margin = 0.1*20)
## End(Not run)
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