stop_rule_d1extended: Generating a stop rule function for EWOC extended model

In ewoc: Escalation with Overdose Control

Description

Generating a stop rule function for EWOC extended model

Usage

stop_rule_d1extended(step)

Arguments

step	an object from the class 'ewoc_d1extended'.

Details

The stop rule function is evaluated at each step of the trial. It can defined based on any information contained in the object 'step' that is the output from one of the functions ewoc_d1extended'.

Value

a logical character indicating if the trial should be stopped or not.

Examples

## Not run: 
DLT <- 0
dose <- 20
step_zero <- ewoc_d1extended(DLT ~ dose, type = 'discrete',
                           theta = 0.33, alpha = 0.25,
                           min_dose = 0, max_dose = 100,
                           dose_set = seq(0, 100, 20),
                           rho_prior = matrix(1, ncol = 2, nrow = 2),
                           rounding = "nearest")
stop_rule_d1extended(step_zero)
response_sim <- response_d1extended(rho = c(0.05, 0.95),
                                   min_dose = 10, max_dose = 50)
sim <- ewoc_simulation(step_zero = step_zero,
                       n_sim = 2, sample_size = 30,
                       alpha_strategy = "conditional",
                       response_sim = response_sim,
                       stop_rule_sim = stop_rule_d1extended,
                       ncores = 1)

## End(Not run)

ewoc documentation built on July 2, 2020, 3:22 a.m.