stop_rule_d1ph: Generating a stopping rule function for EWOC proportional...

In ewoc: Escalation with Overdose Control

Generating a stopping rule function for EWOC proportional hazards model

Description

Generating a stopping rule function for EWOC proportional hazards model

Usage

stop_rule_d1ph(step)

Arguments

step	an object from the class ewoc_d1ph.

Details

The function is evaluated at each step of the trial. It can defined based on any information contained in the object step that is the output from one of the functions ewoc_d1ph.

Value

a logical character indicating if the trial should be stopped or not.

Examples

## Not run: 
time <- 9
status <- 0
dose <- 20
step_zero <- ewoc_d1ph(cbind(time, status) ~ dose, type = 'discrete',
                      theta = 0.33, alpha = 0.25, tau = 10,
                      min_dose = 20, max_dose = 100,
                      dose_set = seq(20, 100, 20),
                      rho_prior = matrix(1, ncol = 2, nrow = 1),
                      mtd_prior = matrix(1, ncol = 2, nrow = 1),
                      distribution = 'exponential',
                      rounding = 'nearest')
stop_rule_d1ph(step_zero)
response_sim <- response_d1ph(rho = 0.05, mtd = 20, theta = 0.33,
                             min_dose = 10, max_dose = 50,
                             tau = 10, distribution = "exponential")
sim <- ewoc_simulation(step_zero = step_zero,
                      n_sim = 2, sample_size = 30,
                      alpha_strategy = "conditional",
                      response_sim = response_sim,
                      stop_rule_sim = stop_rule_d1ph,
                      ncores = 1)

## End(Not run)

ewoc documentation built on Sept. 1, 2026, 1:08 a.m.