Description Usage Arguments Value Examples
Generating a probability of DLT function based on the EWOC classical model
1 | pdlt_d1classical(rho, mtd, theta, min_dose, max_dose)
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rho |
a numerical value indicating the true value of the parameter rho. |
mtd |
a numerical value indicating the true value of the parameter mtd. |
theta |
a numerical value defining the proportion of expected patients to experience a medically unacceptable, dose-limiting toxicity (DLT) if administered the MTD. |
min_dose |
a numerical value defining the lower bound of the support of the MTD. |
max_dose |
a numerical value defining the upper bound of the support of the MTD. |
A function with dose as an input and a probability based on the logistic regression and parameters as an output.
1 2 3 4 | pdlt <- pdlt_d1classical(rho = 0.05, mtd = 60, theta = 0.33,
min_dose = 20, max_dose = 100)
pdlt(20)
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