summary.jointSurroPenal: Short summary of the surrogacy evaluation criteria estimated...

In frailtypack: Shared, Joint (Generalized) Frailty Models; Surrogate Endpoints

Short summary of the surrogacy evaluation criteria estimated from a joint surrogate model

Description

This function returns the estimate of the coefficient, the hazard ratios (HR) and their confidence intervals for the fixed treatment effects. Also, an estimate of the surrogacy evaluation criteria (Kendall's \tau, R²_trial and STE)

Usage

## S3 method for class 'jointSurroPenal'
summary(object, d = 4, len = 3, nb.gh = 32, ...)

Arguments

object	An object inheriting from jointSurroPenal class.
d	The desired number of digits after the decimal point for parameters. The maximum of 4 digits is required for the estimates. Default of 3 digits is used.
len	The desired number of digits after the decimal point for p-value and convergence criteria. Default of 4 digits is used.
nb.gh	Number of nodes for the Gaussian-Hermite quadrature. The default is 32 1 for Gaussian-Hermite quadrature.
...	other unused arguments.

Value

For the fixed treatment effects, it also prints HR and its confidence intervals for each covariate. For the surrogacy evaluation criteria, its prints the estimated Kendall's \tau with its 95% Confidence interval obtained by the parametric bootstrap or Delta-method, the estimated R²_trial(R2trial) with standard error and the 95% Confidence interval obtained by Delta-method (Dowd et al., 2014), R²_trial(R2.boot) and its 95% Confidence interval obtained by the parametric bootstrap. We notice that, using bootstrap, the standard error of the point estimate is not available. We propose a classification of R²_trial according to the suggestion of the Institute of Quality and Efficiency in Health Care (Prasad et al., 2015). We also display the surrogate threshold effect (ste) with the associated hazard risk.

Author(s)

Casimir Ledoux Sofeu [e-mail], [e-mail] and Virginie Rondeau [e-mail]

References

Dowd BE, Greene WH, Norton EC (2014). "Computation of Standard Errors." Health Services Research, 49(2), 731-750.

Prasad V, Kim C, Burotto M, Vandross A (2015). "The strength of association between surrogate end points and survival in oncology: A systematic review of trial-level meta- alyses." JAMA Internal Medicine, 175(8), 1389-1398.

See Also

jointSurroPenal, jointSurroCopPenal, jointSurroTKendall, print.jointSurroPenal

Examples

## Not run: 

###---Data generation---###
data.sim <-jointSurrSimul(n.obs=400, n.trial = 20,cens.adm=549,
          alpha = 1.5, theta = 3.5, gamma = 2.5, zeta = 1,
          sigma.s = 0.7, sigma.t = 0.7, cor = 0.8, betas = -1.25,
          betat = -1.25, full.data = 0, random.generator = 1,
          seed = 0, nb.reject.data = 0)

###---Estimation---###
joint.surrogate <- jointSurroPenal(data = data.sim, nb.mc = 300,
                   nb.gh = 20, indicator.alpha = 1, n.knots = 6)

summary(joint.surrogate)

## End(Not run)

frailtypack documentation built on Oct. 20, 2024, 1:08 a.m.