Hydroquinone Mutagenicity Assay

Description

This data set gives the number of micronuclei per animal and 2000 scored cells for six different groups of differently treated male mice: The negative control (C-), four doses (30, 50, 75, 100 mg hydroquinone / kg) of hydroquinone and an active control (C+) (with 25 mg/kg cyclophosphamide).

Usage

1

Format

A data frame with 31 observations on the following 2 variables:

group

A factor with levels "C-", "30 mg/kg", "50 mg/kg", "75 mg/kg", "100 mg/kg" and "C+" specifying the groups.

micronuclei

A numeric vector, giving the counts of micronuclei per animal and 2000 scored cells after 24h.

Source

Adler, I.-D. and Kliesch, U. (1990): Comparison of single and multiple treatment regimens in the mouse bone marrow micronucleus assay for hydroquinone and cyclophosphamide. Mutation Research 234, 115-123.

References

Bauer, P., Roehmel, J., Maurer, W., and Hothorn, L. (1998): Testing strategies in multi-dose experiments including active control. Statistics in Medicine 17, 2133-2146.

Examples

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