hydroquinone: Hydroquinone Mutagenicity Assay

In gMCP: Graph Based Multiple Comparison Procedures

Hydroquinone Mutagenicity Assay

Description

This data set gives the number of micronuclei per animal and 2000 scored cells for six different groups of differently treated male mice: The negative control (C-), four doses (30, 50, 75, 100 mg hydroquinone / kg) of hydroquinone and an active control (C+) (with 25 mg/kg cyclophosphamide).

Usage

data(hydroquinone)

Format

A data frame with 31 observations on the following 2 variables:

group

A factor with levels "C-", "30 mg/kg", "50 mg/kg", "75 mg/kg", "100 mg/kg" and "C+" specifying the groups.

micronuclei

A numeric vector, giving the counts of micronuclei per animal and 2000 scored cells after 24h.

Source

Adler, I.-D. and Kliesch, U. (1990): Comparison of single and multiple treatment regimens in the mouse bone marrow micronucleus assay for hydroquinone and cyclophosphamide. Mutation Research 234, 115-123.

References

Bauer, P., Roehmel, J., Maurer, W., and Hothorn, L. (1998): Testing strategies in multi-dose experiments including active control. Statistics in Medicine 17, 2133-2146.

Examples

  data(hydroquinone)
  boxplot(micronuclei~group, data=hydroquinone)

gMCP documentation built on May 29, 2024, 9:37 a.m.