smeltz2023.clint.L3: \insertCitesmeltz2023plasma;textualinvitroTKdata Intrinsic...

In invitroTKdata: In Vitro Toxicokinetic Data Processed with the 'invitroTKstats' Pipeline

\insertCitesmeltz2023plasma;textualinvitroTKdata Intrinsic Hepatic Clearance Level-3 Data Set

Description

Frequentist estimate of intrinsic hepatic clearance (Clint) for cryopreserved pooled human hepatocytes. Chemicals were per- and polyfluoroalkyl substance (PFAS) samples. The experiments were led by Dr.s Marci Smeltz and Barbara Wetmore.

Usage

smeltz2023.clint.L3

Format

A level-3 data.frame with 6 rows and 13 variables:

Compound.Name

Compound name

DTXSID

DSSTox Substance Identifier (CompTox Chemicals Dashboard)

Lab.Compound.Name

Compound as described in the laboratory

Calibration

Identifier for mass spectrometry calibration – usually the date

Clint

Frequentist point estimate for intrinsic hepatic clearance (Clint)

Clint.pValue

p-value of the estimated Clint value

Fit

Test nominal concentrations in the linear regression fit

AIC

Akaike Information Criterion (AIC) for the linear regression fit

AIC.Null

Akaike Information Criterion of the exponential decay assuming a constant rate of decay

Clint.1

Intrinsic hepatic clearance at 1 uM (frequentist point estimate)

Clint.10

Intrinsic hepatic clearance at 10 uM (frequentist point estimate)

AIC.Sat

Akaike Information Criterion of the exponential decay with a saturation probability

Sat.pValue

p-value of exponential decay with a saturation probability

References

\insertRef

shibata2002predictioninvitroTKdata

\insertRef

smeltz2023plasmainvitroTKdata

invitroTKdata documentation built on Aug. 21, 2025, 5:56 p.m.