smeltz2023.clint.L4: \insertCitesmeltz2023plasma;textualinvitroTKdata Intrinsic...

In invitroTKdata: In Vitro Toxicokinetic Data Processed with the 'invitroTKstats' Pipeline

\insertCitesmeltz2023plasma;textualinvitroTKdata Intrinsic Hepatic Clearance Level-4 Data Set

Description

Bayesian estimate of intrinsic hepatic clearance (Clint) for cryopreserved pooled human hepatocytes. Chemicals were per- and polyfluoroalkyl substance (PFAS) samples. The experiments were led by Dr.s Marci Smeltz and Barbara Wetmore.

Usage

smeltz2023.clint.L4

Format

A level-4 data.frame with 7 rows and 12 variables:

Compound.Name

Compound name

DTXSID

DSSTox Substance Identifier (CompTox Chemicals Dashboard)

Lab.Compound.Name

Compound as described in the laboratory

Clint.1.Med

Posterior median intrinsic hepatic clearance at 1 uM

Clint.1.Low

Posterior 2.5th quantile of intrinsic hepatic clearance at 1 uM (lower credible interval bound)

Clint.1.High

Posterior 97.5th quantile of intrinsic hepatic clearance at 1 uM (upper credible interval bound)

Clint.10.Med

Posterior median intrinsic hepatic clearance at 10 uM

Clint.10.Low

Posterior 2.5th quantile of intrinsic hepatic clearance at 10 uM (lower credible interval bound)

Clint.10.High

Posterior 97.5th quantile of intrinsic hepatic clearance at 10 uM (upper credible interval bound)

Clint.pValue

Probability that a chemical concentration decrease is observed

Sat.pValue

Probability that a lower Clint is observed at a higher concentration, i.e. saturation probability

degrades.pValue

Probability of abiotic degradation

References

\insertRef

shibata2002predictioninvitroTKdata

\insertRef

smeltz2023plasmainvitroTKdata

invitroTKdata documentation built on Aug. 21, 2025, 5:56 p.m.