wambaugh2019.clint.L3: \insertCitewambaugh2019assessing;textualinvitroTKdata...

In invitroTKdata: In Vitro Toxicokinetic Data Processed with the 'invitroTKstats' Pipeline

\insertCitewambaugh2019assessing;textualinvitroTKdata Intrinsic Hepatic Clearance Level-3 Data Set

Description

Frequentist estimate of intrinsic hepatic clearance (Clint) measured using in vitro suspensions of pooled primary human hepatocytes \insertCiteshibata2002predictioninvitroTKdata.

Usage

wambaugh2019.clint.L3

Format

A data.frame with 473 rows and 13 variables:

Compound.Name

Compound name

DTXSID

DSSTox Substance Identifier (CompTox Chemical Dashboard)

Lab.Compound.Name

Compound as described in the laboratory

Calibration

Identifier for mass spectrometry calibration - usually the date

Clint

Frequentist point estimate for intrinsic hepatic clearance (Clint)

Clint.pValue

p-value of the estimated Clint value

Fit

Test nominal concentrations in the linear regression fit

AIC

Akaike Information Criterion (AIC) for the linear regression fit

AIC.Null

Akaike Information Criterion of the exponential decay assuming a constant rate of decay

Clint.1

Intrinsic hepatic clearance at 1 uM (frequentist point estimate)

Clint.10

Intrinsic hepatic clearance at 10 uM (frequentist point estimate)

AIC.Sat

Akaike Information Criterion of the exponential decay with a saturation probability

Sat.pValue

p-value of exponential decay with a saturation probability

Source

Wambaugh et al. (2019)

References

\insertRef

shibata2002predictioninvitroTKdata

\insertRef

wambaugh2019assessinginvitroTKdata

invitroTKdata documentation built on Aug. 21, 2025, 5:56 p.m.