liver: Liver cirrhosis drug trial data

In joineR: Joint Modelling of Repeated Measurements and Time-to-Event Data

Liver cirrhosis drug trial data

Description

This dataset gives the longitudinal observations of prothrombin index, a measure of liver function, for patients from a controlled trial into prednisone treatment of liver cirrhosis. Time-to-event information in the form of the event time and associated censoring indicator are also recorded along with a solitary baseline covariate - the allocated treatment arm in this instance. The data are taken from Andersen et al. (1993, p. 19) and were analyzed in Henderson et al. (2002). This is a subset of the full data where a number of variables were recorded both at entry and during the course of the trial.

Usage

data(liver)

Format

A data.frame in the unbalanced format with longitudinal observations from 488 subjects. The columns are:

id

integer: number for patient identification.

prothrombin

integer: prothrombin index measurement (%).

time

numeric: time of prothrombin index measurement (years).

treatment

integer: patient treatment indicator. Coded as 0 = placebo; 1 = prednisone.

survival

numeric: patient survival time (years).

cens

integer: censoring indicator. Coded as 1 = died; 0 = censored.

Source

Skrondal A, Rabe-Hesketh S. Generalized Latent Variable Modeling: Multilevel, Longitudinal and Structural Equation Models. Chapman & Hall/CRC. 2004. URL: http://www.gllamm.org/books/readme.html#14.6.

References

Andersen PK, Borgan O, Gill RD, Kieding N. Statistical Models Based on Counting Processes. New York: Springer. 2003.

Henderson R, Diggle PJ, Dobson A. Identification and efficacy of longitudinal markers for survival. Biostatistics 2002; 3: 33-50.

See Also

heart.valve, epileptic, mental, aids.

joineR documentation built on Jan. 23, 2023, 5:39 p.m.